ID A0A0L8I0W2_OCTBM Unreviewed; 846 AA.
AC A0A0L8I0W2;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=WD repeat-containing protein 91 {ECO:0000256|ARBA:ARBA00021116};
GN ORFNames=OCBIM_22039652mg {ECO:0000313|EMBL:KOF95074.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF95074.1};
RN [1] {ECO:0000313|EMBL:KOF95074.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF95074.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF95074.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004220}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004220}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004414}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR91 family.
CC {ECO:0000256|ARBA:ARBA00006128}.
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DR EMBL; KQ416811; KOF95074.1; -; Genomic_DNA.
DR RefSeq; XP_014767766.1; XM_014912280.1.
DR AlphaFoldDB; A0A0L8I0W2; -.
DR STRING; 37653.A0A0L8I0W2; -.
DR EnsemblMetazoa; Ocbimv22039652m; Ocbimv22039652m.p; Ocbimv22039652m.g.
DR EnsemblMetazoa; XM_014912280.1; XP_014767766.1; LOC106867412.
DR OMA; KMYLVNA; -.
DR OrthoDB; 5482780at2759; -.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0141039; F:phosphatidylinositol 3-kinase inhibitor activity; IEA:InterPro.
DR GO; GO:0045022; P:early endosome to late endosome transport; IEA:InterPro.
DR GO; GO:0051898; P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR006594; LisH.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR039724; WDR91.
DR PANTHER; PTHR13083; UNCHARACTERIZED; 1.
DR PANTHER; PTHR13083:SF3; WD REPEAT-CONTAINING PROTEIN 91; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50896; LISH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT REPEAT 503..534
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 663..714
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 665..699
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 808..846
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 204..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 390..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..369
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..445
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 846 AA; 94283 MW; 4BC8048255D37EE5 CRC64;
MAAAATHVDE LVKEYLLQRG LTSSFRAFEL ELKNEKEKGL RVDKLLDQLQ QYISSFDLTS
LRDYWSRLNT RLFSRLDQRY MAGVRKMEVG LLKFYLIYAT QNNKHDKIME FFEKLTMELQ
NQPEFREWFI LPFVRNPEEH PLFSIHFTRQ WQETYFLSLH NFLSAVLQVI PRPTLLAFEE
DTLQKKKILQ ENEMLKMKLH AQIQAEAAKH SNSGERRHTV SADHVHPSEE LIFDFSGLSD
ESLNEKTKKT GKRFALNFSS SPLLGKKLSV ATLKKSESST APKEVPKSSK NRNNQGFPII
NGAQANTSGL KVGSVGNISG SPSHSEESLS GVASSRSRHQ MEEYEKQRRA LLGLSDSSRS
KDKRPSEGDV TASRYQGSQR LANFFRSSSQ AEIDVNSTSP DIRSTGSSPS NFMIGCLNES
PSFSLNDRHG QGQVQGRSGS DPALGEASSS ILFGGMKKDL SDNEAYGRAD KLQATESNSP
SNYSKVSDDS EELPFLLLSQ EEYGEHRSGI CYCRFSNSGQ YVASLDADGV VKVWTWSPQP
ATKATCMAKS PFLSLEWSQK SDRLLLLGNR SGNIRLFDVK DKRSVVEACT DQSYPRICCL
CSSPSTNQFV CSATTSKMKS GNVTSSNGGQ STAAASRIGR LSIWNLKTMK MEKTLPIDGG
GFVAVNCCAF NHNGQLLIVG AVDGAVRMFD MQQQKTIAKW AAHEGEVLSL QFSSDETSCF
TMGIDNKFYQ WSILQPGKKL TEFVIFHTAT SPIIINKPFS GRETLYGRSF AFDSEGHYML
TCHKNEGIIY EINSEGSSGC YADKHMLLKG HQGLVTTVDW SPSVDTRICL TGSLDGKVKI
STMLTK
//
