ID A0A0L8IFN3_OCTBM Unreviewed; 1387 AA.
AC A0A0L8IFN3;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Agrin {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=OCBIM_22005418mg {ECO:0000313|EMBL:KOG00301.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOG00301.1};
RN [1] {ECO:0000313|EMBL:KOG00301.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOG00301.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOG00301.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; KQ415816; KOG00301.1; -; Genomic_DNA.
DR STRING; 37653.A0A0L8IFN3; -.
DR EnsemblMetazoa; Ocbimv22005418m; Ocbimv22005418m.p; Ocbimv22005418m.g.
DR OMA; NECIMRQ; -.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00055; EGF_Lam; 2.
DR CDD; cd00104; KAZAL_FS; 6.
DR CDD; cd00110; LamG; 3.
DR Gene3D; 2.60.120.200; -; 3.
DR Gene3D; 3.30.60.30; -; 6.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR003884; FacI_MAC.
DR InterPro; IPR003645; Fol_N.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR15036:SF83; AGRIN; 1.
DR PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF07648; Kazal_2; 6.
DR Pfam; PF00053; Laminin_EGF; 2.
DR Pfam; PF00054; Laminin_G_1; 2.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00180; EGF_Lam; 2.
DR SMART; SM00057; FIMAC; 2.
DR SMART; SM00274; FOLN; 8.
DR SMART; SM00280; KAZAL; 6.
DR SMART; SM00282; LamG; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 6.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01248; EGF_LAM_1; 1.
DR PROSITE; PS50027; EGF_LAM_2; 2.
DR PROSITE; PS51465; KAZAL_2; 6.
DR PROSITE; PS50025; LAM_G_DOMAIN; 3.
PE 4: Predicted;
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 26..73
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 98..144
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 159..213
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 231..278
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 316..363
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 414..466
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 467..513
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 540..587
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 687..724
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 729..914
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 915..952
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 953..990
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 997..1178
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1174..1210
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1216..1387
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DISULFID 414..426
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 416..433
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 435..444
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 467..479
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 469..486
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 488..497
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 714..723
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 942..951
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 980..989
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1200..1209
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KOG00301.1"
SQ SEQUENCE 1387 AA; 153071 MW; 0AD204BEAA79F393 CRC64;
GTNPCANKCR KYERCNINRQ GVAECVCPTS CEPVLRPICG SDGVTYDNEC QLQKDACQNE
LPIILKQRGP CGVKQPCLNH HCNFHGVCVV REGRAECDCP TCSEEFDPVC GMNGISYTNE
CKLRLENCQK RSDVKVKHKG LCNGCENQRC EFYAVCQSDG KNAKCVCPSA CVEVENKVCG
TNRISYQNEC ELKVASCRDQ KLIEVESRGD CNKCAKIRCP FGSTCENGMC VCPSECPADF
EVLCASNGQV YNNECEMKRY ACLKKTELYI VNNGPCDEIS GSGIVEGSGS GSICDETSCK
FGGTCELSEG SNYHCTCKNI CDAIRSIVCG SDGKTYGNDC MMKLESCYQQ QEITAVASEN
CEDLEEEPCD GNMPLVNPLT GQEYYCYDDK NICPAGSYCH KRATFAKCCR EGSCQCNPLG
SYGTSCDPHT RQCVCKPGVG GLRCDRCKPG NWGLLSIVKG SAGCIPCNCN RYGSVRDDCE
QNSGRCMCKN GITGMKCNVC PNRMQLGPQG CTEIPPKSCQ YLHCKYGAVC KRIDNQHQCV
CNINCSGYPD LVCGSDNQTY GSECQLKQFS CRLQQPISIE HKGICSLVST ESRMVTSPTP
TTRSRKTTRH INHVSNEVTK IILTKATERP PEVVGRIDDL CPSESDCDVP NSRCVLGICV
CKTGFIQTMD KKNCLEVVSV PPPSPTSNTT CTLNPCQNGG TCLMDKTLGY RCLCPLGTGG
SICKDVVSFT VPSFSGTSYL RMPQIKNATT EMRIEVEFKS LNKDGIILFN SKEEDGSGDF
VSLTLNQGFV ELRYDLGNGL AIIRSAKPIR LNKYHHVIAR RIGQDGFLQV DGQSNTAESS
SPGDLTSLNL ESPLYLGHIQ NFTSLVKSRI DVEVGLVGCI RKVIAGKRQS PYTYRLAYPD
ELSDVIDGVD IAECGNNPCS SMPCKNGGNC LMLDNVMVQC ICQEGFIGKY CENEDMCINN
PCQGGGTCTP TDHGSYVCIC PEDRKGRNCQ EEVLQRLDVP EFNGTSYVEL PLNDSDLLDT
MTIAVWFKTT KPDGMLFYAS QYSGGEGDFI ALNLENYYVE FSFNLGGGTT KVRSSQRISL
DSWHNVVIKR HHRTIEMIID NEKSADGKSD GVVTKLNLAQ RIFIGGFRDI FDVPSDTNIE
KGLNGAIQRV YINDKLYDNL ITDAIETKGV TKYKGPPCKK NPCLNGGICV PKLHIAECRC
HKQFTGHKCQ NAIETKSQLK FEGDTFLAYL NGLDHKKTSQ QANKFRLRFK SKKRSGLLFI
MNQGNTVRQD YFAVALVKGK MQLSYNLGAQ TEENLHIIRS TLKIKNNEWH VIEVERNQEE
GILRVDDAVP VKRSSLSGAT KLDTDGELWI GGKKNLPMGL PKDYYVGFEG CMDFVEVDDQ
RLNLDFF
//
