ID A0A0M0BJ68_9ARCH Unreviewed; 492 AA.
AC A0A0M0BJ68;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Argininosuccinate lyase {ECO:0000256|HAMAP-Rule:MF_00006};
DE Short=ASAL {ECO:0000256|HAMAP-Rule:MF_00006};
DE EC=4.3.2.1 {ECO:0000256|HAMAP-Rule:MF_00006};
DE AltName: Full=Arginosuccinase {ECO:0000256|HAMAP-Rule:MF_00006};
GN Name=argH {ECO:0000256|HAMAP-Rule:MF_00006};
GN ORFNames=AC481_01965 {ECO:0000313|EMBL:KON28385.1};
OS miscellaneous Crenarchaeota group archaeon SMTZ-80.
OC Archaea; Candidatus Bathyarchaeota.
OX NCBI_TaxID=1685135 {ECO:0000313|EMBL:KON28385.1, ECO:0000313|Proteomes:UP000037599};
RN [1] {ECO:0000313|EMBL:KON28385.1, ECO:0000313|Proteomes:UP000037599}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SMTZ-80 {ECO:0000313|EMBL:KON28385.1};
RA Lazar C.S., Baker B.J., Seitz K.W., Hyde A.S., Dick G.J., Hinrichs K.-U.,
RA Teske A.P.;
RT "New insights into the roles of widespread benthic archaea in carbon and
RT nitrogen cycling.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC ChEBI:CHEBI:57472; EC=4.3.2.1; Evidence={ECO:0000256|HAMAP-
CC Rule:MF_00006};
CC -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC from L-ornithine and carbamoyl phosphate: step 3/3. {ECO:0000256|HAMAP-
CC Rule:MF_00006}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00006}.
CC -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC subfamily. {ECO:0000256|HAMAP-Rule:MF_00006}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KON28385.1}.
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DR EMBL; LFWY01000006; KON28385.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M0BJ68; -.
DR PATRIC; fig|1685135.3.peg.1481; -.
DR UniPathway; UPA00068; UER00114.
DR Proteomes; UP000037599; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004056; F:argininosuccinate lyase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR CDD; cd01359; Argininosuccinate_lyase; 1.
DR Gene3D; 1.10.40.30; Fumarase/aspartase (C-terminal domain); 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR HAMAP; MF_00006; Arg_succ_lyase; 1.
DR InterPro; IPR029419; Arg_succ_lyase_C.
DR InterPro; IPR009049; Argininosuccinate_lyase.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR NCBIfam; TIGR00838; argH; 1.
DR PANTHER; PTHR43814; ARGININOSUCCINATE LYASE; 1.
DR PANTHER; PTHR43814:SF1; ARGININOSUCCINATE LYASE; 1.
DR Pfam; PF14698; ASL_C2; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00145; ARGSUCLYASE.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|HAMAP-Rule:MF_00006};
KW Arginine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00006};
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00006};
KW Lyase {ECO:0000256|HAMAP-Rule:MF_00006}.
FT DOMAIN 7..299
FT /note="Fumarate lyase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00206"
FT DOMAIN 363..437
FT /note="Argininosuccinate lyase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14698"
SQ SEQUENCE 492 AA; 55992 MW; 8BDA5E8246D5A233 CRC64;
MYRSRLGKQT DDFAIKFMSS ISDDDWILME DVENTEAHDI MLQEQGIIEL NDLRKILKNL
EEVKLKFKSE KLSISGSFED IHEFIEHTIT KKVGIEIGGK IHTGRSRNDQ VATDIRMKVR
TELLEVFQVI LNLIDILVNL ANRNINTVMV MYTHTQQAQI GNFAHYLIAH IDHLYRDIER
IISCYKRVNL SPLGSSAIGG SSFNLNRIRT AELLGFDGLV ENSIDSISAR DFALEAVSVL
ALIMSNVSRI AEDMILWSTN EFGFIEIADE YASTSSVMPQ KKNPCSLELI RARTGRVYGN
LLELLTIIKG LPTGYNRDLQ ETKQPLKSSF EIVKETLEIL CRIFNTIKIN KEMMFNTASE
SHAMALDLAD ELVRDGLSFR ESHKLVGEVV RTLVKTNKRI TEINSQFLEK ISNKILNKKI
SITDKKIKDV LDPNYSLSKR STIGSANPIF VKRMIKERMK KSSILKKEFA NRENRINEAK
KLLSKTIGSI LS
//
