ID A0A0M0CDW8_LACPN Unreviewed; 282 AA.
AC A0A0M0CDW8;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=2,5 diketo-D-gluconic acid-like reductase {ECO:0000313|EMBL:BBA81858.1};
DE EC=1.1.1.- {ECO:0000313|EMBL:BBA81858.1};
DE SubName: Full=2,5-diketo-D-gluconic acid reductase {ECO:0000313|EMBL:AOB22245.1};
DE SubName: Full=Oxidoreductase of aldo/keto reductase family subgroup 1 {ECO:0000313|EMBL:KZU97043.1};
DE SubName: Full=Putative oxidoreductase {ECO:0000313|EMBL:QHM36804.1};
DE EC=1.-.-.- {ECO:0000313|EMBL:QHM36804.1};
GN ORFNames=AVR83_04540 {ECO:0000313|EMBL:AOB22245.1}, C7M36_01074
GN {ECO:0000313|EMBL:QHM36804.1}, Lp19_1019
GN {ECO:0000313|EMBL:KZU97043.1}, SN35N_1479
GN {ECO:0000313|EMBL:BBA81858.1};
OS Lactiplantibacillus plantarum (Lactobacillus plantarum).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactiplantibacillus.
OX NCBI_TaxID=1590 {ECO:0000313|EMBL:KZU97043.1, ECO:0000313|Proteomes:UP000076882};
RN [1] {ECO:0000313|EMBL:AOB22245.1, ECO:0000313|Proteomes:UP000093296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DF {ECO:0000313|EMBL:AOB22245.1,
RC ECO:0000313|Proteomes:UP000093296};
RA Petkau K., Fast D., Duggal A., Foley E.;
RT "Comparative evaluation of the genomes of common bacterial members of the
RT Drosophila intestinal community.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KZU97043.1, ECO:0000313|Proteomes:UP000076882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=19.1 {ECO:0000313|EMBL:KZU97043.1,
RC ECO:0000313|Proteomes:UP000076882};
RA Martino M.E.;
RT "Comparative genomics of 54 Lactobacillus plantarum strains reveals genomic
RT uncoupling from niche constraints.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:BBA81858.1, ECO:0000313|Proteomes:UP000269784}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SN35N {ECO:0000313|EMBL:BBA81858.1,
RC ECO:0000313|Proteomes:UP000269784};
RX PubMed=29607926; DOI=.1248/bpb.b17-00840;
RA Noda M., Shiraga M., Kumagai T., Danshiitsoodol N., Sugiyama M.;
RT "Characterization of the SN35N Strain-Specific Exopolysaccharide Encoded in
RT the Whole Circular Genome of a Plant-Derived Lactobacillus plantarum.";
RL Biol. Pharm. Bull. 41:536-545(2018).
RN [4] {ECO:0000313|EMBL:QHM36804.1, ECO:0000313|Proteomes:UP000464882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SRCM101167 {ECO:0000313|EMBL:QHM36804.1,
RC ECO:0000313|Proteomes:UP000464882};
RA Jeong D.-Y.;
RT "Lactobacillus plantatrum SRCM101167 having anti-virus activity species
RT isolated from Korea kimchi.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP013753; AOB22245.1; -; Genomic_DNA.
DR EMBL; AP018405; BBA81858.1; -; Genomic_DNA.
DR EMBL; LUXM01000018; KZU97043.1; -; Genomic_DNA.
DR EMBL; CP028334; QHM36804.1; -; Genomic_DNA.
DR RefSeq; WP_003646328.1; NZ_WWDF01000003.1.
DR GeneID; 79831143; -.
DR KEGG; lpb:SH83_00585; -.
DR PATRIC; fig|1590.142.peg.138; -.
DR OMA; ACATNQV; -.
DR Proteomes; UP000076882; Unassembled WGS sequence.
DR Proteomes; UP000093296; Chromosome.
DR Proteomes; UP000269784; Chromosome.
DR Proteomes; UP000464882; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR CDD; cd19071; AKR_AKR1-5-like; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:BBA81858.1}.
FT DOMAIN 18..267
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 53
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 111
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 78
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 282 AA; 30820 MW; 06889AF05A74357C CRC64;
MTVLTTMYQL ANGVNIPKVA FGTWQIPGGE ATYQAVRAAL AAGYRHIDTA LAYQNEASVG
QAIRDSGIPR EQIFVTTKLP AETKSYQGAL NDFDRSLKNL GLDYVDLYLV HAPWPWGQVG
RVYDEANLDV WQAMEAIYQS GRAKAIGVSN FAVRDLKNIL NQATIPPMVN QIQYYLGFTE
PKITKFSEEH AMLVEAYSPL ATGGVLDNPQ VQAYADKYGV SVAQLALRFV LQNGVLPLPK
AVNPAHIEAN TQLDFAISVA DMQALNDLPD AAGSYMHNPT QG
//
