ID A0A0M0FZ93_9BACI Unreviewed; 1177 AA.
AC A0A0M0FZ93;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=AF331_21550 {ECO:0000313|EMBL:KON82697.1};
OS Rossellomorea marisflavi.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Rossellomorea.
OX NCBI_TaxID=189381 {ECO:0000313|EMBL:KON82697.1, ECO:0000313|Proteomes:UP000037405};
RN [1] {ECO:0000313|Proteomes:UP000037405}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 11544 {ECO:0000313|Proteomes:UP000037405};
RA Liu B., Wang J., Zhu Y., Liu G., Chen Q., Chen Z., Lan J., Che J., Ge C.,
RA Shi H., Pan Z., Liu X.;
RT "Fjat-14235 jcm11544.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KON82697.1}.
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DR EMBL; LGUE01000010; KON82697.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M0FZ93; -.
DR STRING; 189381.GCA_900166615_04432; -.
DR PATRIC; fig|189381.12.peg.3991; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000037405; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR CDD; cd18810; SF2_C_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR048635; MFD_D3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21132; MFD_D3; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000037405}.
FT DOMAIN 638..799
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 820..974
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1177 AA; 134010 MW; 86AFF3C992AB6378 CRC64;
MKGILTYVHQ SEEVQSLITG IEERLSEQLV AGLSGSSRSA YIADVYLQTK RSTIVVTHNL
FQAQKIYEDL VQFLSEDEVY LYSANELIAA ELSVASPELR AQRIEVLNKL SQRQNGVYIV
PVSGLRKILP PMDLWIKNQI RFNVGEDIDL DEVLNQLVQM GYQRAGMVST PGEFSLRGGI
VDIFPLTSQH PVRIELFDTE IDSIRMFSVE DQRSIDKLKT VDIGPATEVL LTYQNIERLI
GEINKGLSKS LKKIKSAGVK EKMTEYIGHE VEQLENGQVP EQIFKYLSLA YETPASLLDY
LPEDGVLFFD EYSRVQEMSE SLEKEEAEWY TSLLSEGQII HDMVVSHPFA SLVSNAKRSK
VYFSLFLRQI PNTSPQNIFN VSTKPMQNFH GQMNVLKAEL DRWKKGKYTV VLLGPDEERV
KKLQRVLDDY QIEIAFVKDG GSLLNGKVQM INGSLTNGFE LPLQKLAVIT EEELFNKRTQ
KKPRRQKMSN AERIKSYSEL KVGDLVVHVN HGIGKYLGIE TLEINGVHKD YLHLKYQGSD
KLYVPVDQID LVQKYVASEN KDPKLYKLGG NEWKKVKSKV ASSVQDIADD LIKLYAEREA
AKGYAFSPDG DMQREFEIAF PYEETEDQLR SIHEIKLDME RERPMDRLLC GDVGYGKTEV
AIRAAFKAIA DGKQVALLVP TTILAQQHYE TIKERFQDFP VEISLLSRFR TRKQQQETTK
GLKDGTVDIV VGTHRLLSKD IQYRDLGLLI IDEEQRFGVT HKEKIKQLKT NIDVLTLTAT
PIPRTLHMSM LGVRDLSVIE TPPENRFPVQ TYVMEYNGAL IKEAIEREMA RNGQVYFLYN
RVEDIERKAD EISMLVPDAR VAYAHGQMSE NELEAVILGF LAGEYDVLVT TTIIETGVDI
PNVNTLIVFD ADRMGLSQLY QLRGRVGRSN RVAYSYFTYR KDKVLTEVAE KRLQAIKEFT
ELGSGFKIAM RDLTIRGAGN LLGAQQHGFI DSVGFDLYSQ MLKEAIEERK GDRPKQPEAS
LEVDLDLDAY IPDTYIKDGH QKIEMYKRFR ALSSLKEVEE LEEEILDRFG EYPEEVGYLF
LISEMKVYAR NTRLDSVKQD KKSVNIFMSP EGTAAIDGSK VFDICSKHGR VVGLGMEGSK
LKISINTTRL KADKWFNMAY DIVKNLDQAL KTEVHEA
//
