ID A0A0M0J6G1_9EUKA Unreviewed; 492 AA.
AC A0A0M0J6G1;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Microsomal glutathione s-transferase {ECO:0000313|EMBL:KOO21818.1};
GN ORFNames=Ctob_004874 {ECO:0000313|EMBL:KOO21818.1};
OS Chrysochromulina tobinii.
OC Eukaryota; Haptista; Haptophyta; Prymnesiophyceae; Prymnesiales;
OC Chrysochromulinaceae; Chrysochromulina.
OX NCBI_TaxID=1460289 {ECO:0000313|EMBL:KOO21818.1, ECO:0000313|Proteomes:UP000037460};
RN [1] {ECO:0000313|Proteomes:UP000037460}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP291 {ECO:0000313|Proteomes:UP000037460};
RX PubMed=26397803; DOI=10.1371/journal.pgen.1005469;
RA Hovde B.T., Deodato C.R., Hunsperger H.M., Ryken S.A., Yost W., Jha R.K.,
RA Patterson J., Monnat R.J. Jr., Barlow S.B., Starkenburg S.R.,
RA Cattolico R.A.;
RT "Genome Sequence and Transcriptome Analyses of Chrysochromulina tobin:
RT Metabolic Tools for Enhanced Algal Fitness in the Prominent Order
RT Prymnesiales (Haptophyceae).";
RL PLoS Genet. 11:e1005469-e1005469(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOO21818.1}.
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DR EMBL; JWZX01003332; KOO21818.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M0J6G1; -.
DR OrthoDB; 5487436at2759; -.
DR Proteomes; UP000037460; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003676; F:nucleic acid binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006691; P:leukotriene metabolic process; IEA:UniProt.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 1.20.120.550; Membrane associated eicosanoid/glutathione metabolism-like domain; 1.
DR Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR InterPro; IPR023352; MAPEG-like_dom_sf.
DR InterPro; IPR001129; Membr-assoc_MAPEG.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR10250; MICROSOMAL GLUTATHIONE S-TRANSFERASE; 1.
DR PANTHER; PTHR10250:SF26; S-TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08370)-RELATED; 1.
DR Pfam; PF01124; MAPEG; 1.
DR Pfam; PF01424; R3H; 1.
DR SMART; SM00393; R3H; 1.
DR SUPFAM; SSF161084; MAPEG domain-like; 1.
DR SUPFAM; SSF82708; R3H domain; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS51061; R3H; 1.
DR PROSITE; PS50030; UBA; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000037460};
KW Transferase {ECO:0000313|EMBL:KOO21818.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 432..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 471..491
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 15..77
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
FT DOMAIN 153..203
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT REGION 208..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..238
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 492 AA; 51702 MW; 738D6D75FD3E6847 CRC64;
MGFSVESLAV AKAQPAWVRQ VDELLSAFCR GDARRESLPA MTKQQRGVVH EMAKAYNIST
QSYDNEPRRH VDLFRTPTTL LSAGRVAESL ITQATSGAPH ASGPSGAAAG YGFGGGLAEY
CIDLVDVQCS QAAMATTLRA LSGDYSVRLG PPPPDGSAPK ASVPLPPAIL EVAALGFTPD
QAAFALQSTG GHVAQAIELL IAQGGADSQG WRELPNKGGS GGAAEERRRA EPHSGGETRA
SVEGRSGAGA RDGATELDPP VPSPLSNKKR EQPAAAESAS AAAADGSNTS LDRALGGAPT
DHTLVTELQA LGYPLLACRT AARVVTSEHK DAGRAAWLEA GKAWLQDKVD KGELKAPMPK
TAPVPAPAPP APTAAEARKK NDVQYPNLYA TPGYHKEADA FNRVQRGHQN MFESLSSMQT
MSLLGGLKHP KVAAVGFCLY LAGCYFYMVG YSDMSLDVKT ARYKRGGGLK WLGILACMYT
STSLAGSMLR WW
//
