ID A0A0M0JBP4_9EUKA Unreviewed; 1807 AA.
AC A0A0M0JBP4;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Sodium channel protein type 2 subunit alpha {ECO:0000313|EMBL:KOO23915.1};
GN ORFNames=Ctob_007596 {ECO:0000313|EMBL:KOO23915.1};
OS Chrysochromulina tobinii.
OC Eukaryota; Haptista; Haptophyta; Prymnesiophyceae; Prymnesiales;
OC Chrysochromulinaceae; Chrysochromulina.
OX NCBI_TaxID=1460289 {ECO:0000313|EMBL:KOO23915.1, ECO:0000313|Proteomes:UP000037460};
RN [1] {ECO:0000313|Proteomes:UP000037460}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP291 {ECO:0000313|Proteomes:UP000037460};
RX PubMed=26397803; DOI=10.1371/journal.pgen.1005469;
RA Hovde B.T., Deodato C.R., Hunsperger H.M., Ryken S.A., Yost W., Jha R.K.,
RA Patterson J., Monnat R.J. Jr., Barlow S.B., Starkenburg S.R.,
RA Cattolico R.A.;
RT "Genome Sequence and Transcriptome Analyses of Chrysochromulina tobin:
RT Metabolic Tools for Enhanced Algal Fitness in the Prominent Order
RT Prymnesiales (Haptophyceae).";
RL PLoS Genet. 11:e1005469-e1005469(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOO23915.1}.
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DR EMBL; JWZX01003145; KOO23915.1; -; Genomic_DNA.
DR OrthoDB; 2966630at2759; -.
DR Proteomes; UP000037460; Unassembled WGS sequence.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF62; SODIUM CHANNEL PROTEIN 60E; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808}; Ion channel {ECO:0000313|EMBL:KOO23915.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR602077-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000037460};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022568, ECO:0000256|RuleBase:RU003808};
KW Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 94..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 413..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 533..557
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 638..657
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 736..764
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 882..905
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 925..945
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1017..1041
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1217..1239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1300..1318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1338..1355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1367..1389
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1438..1460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1594..1617
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 89..447
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 487..769
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 885..1248
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1297..1626
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 775..800
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 398
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 713
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
SQ SEQUENCE 1807 AA; 204345 MW; B6772A9562397D1F CRC64;
MEEPVEAARL ADDEPDTSDA AAAAASVATG HQDSPRSEAS GRGIMEMVAK IATGGERLTD
EKYAPKAWIF LHRDRFPRKQ CIAIIENVWF DRCVLALIGL NCLTMVLFAS PLVASVLAND
DGVDYRDIEQ KSAWVARHWT FELLKPLRDQ GNCGLGDRIP CSFSQIVDFV FLLFFAIEMV
IKMLALGLAL HKNAYLRSGW NWLDFVVVVV GFLEQFSGGD LPGISTIRLV KTFRPLRSMQ
RIRGLRVLVQ TILEALPQML NVAIFLVFVL IIFGLFGMAF FSGKLRHACH ACAEYDEAGE
CLEWESTGIR CDAECQWDDD IRLVKACGSL GNGTMQKESQ ARNLRWTYSC RPGERCLCDD
SGEALPGCSY LANPNYGITS FDSILWAMLS LFQAISLEGW IDMTYQLMDG CSMFVFIYFI
VLVLIGAIIA MNLFLAVLCD NFDKADSDDT NPMSDEESSE EVLARQLMQM KHSNIIRQRC
LDVIRFKYFD YFIQGCILLN TLLMCLKVAP QPANLVAMDI HTIPRWDYLP EPYFWFLTIF
NIILTLVFVA ELVLKMVALG WRLFLRDSMN LFDAFVVFFS IVELALDLSE RFSTGGAVIP
LPLSVLRAFR IFRLFKLVRT IDSLRKIIST LIQSFKEVFY LALLLLLVML IFILLGVELF
GGMYPHSEYN YTQDNFPGTW DKRMILWEDD ASRYNFDDFG TALLAIFVVL SGENWNEIMF
NNHEATWSKD VAAVPFIPWA VIYMVILFIV GNLLLFNLFV AILLSNFDDD DDFADAEEDE
DARNEAMEDD IGDSKAAKAR KQKPEEVEYK FGEYRLKSVA RRGSVVGDAG GVDDDDKGED
EEVPEAQIVI EAYPKSVTDG GGDKSLMIFG WDNPVRIVCC RIILHPVFEP VVLVLILVST
LTLVIDMPHL DYKSPLRSGI EKLNTVFTVL FTLEMALKMV ACGLYKSKTP PKYTLHMPYF
ASSWNILDFF IVLVTILSDV LDPAEQPWIN QLRTFRAIRP LRLVSRYEAL KVTCSTLLAA
IPAMASLATV AILFFLIFGI LGTELFGGKF GYCYDPLYAD LEFGGRITPG LGMGPHAHQG
ANTDYHECMA LPRYNLTRRT TDGILLMDMA DIEPGTLSDG SKWLNFIEFP QWVYPSFGNF
DNIGYSFILL FEVSALEGWP DVMHWAMDVD SNEMYVQPWR IDSNPMEWMA SDTPVPEELL
PSIPSHKHTT ANIEGGAFFV LWIIFGCFVI VNLTVGIVVD TFSDIKAKND GLLNMTEDQA
DWVLAQKQLL TQRPLKAATQ PAQLWRHNFY YLVTSTRFEV FIMVVIMMNM TFMACDWFEP
NPDAQIYIPQ LKHTMKVVDA VFFFIYVAEM LLKWVGLGFD QYFKDSWCVF DCILVTISAV
DFIFTWIVVD GKMPFPAAVA RCLRLFRVAR ILRIVKTAKS LRVIMLTVYL SLPQLYNIMI
LITLIILITD MLLVGFFWFV NYTPGNFDTS DHLDWTVTQS YRKGERYFQD DWHLDNTPGT
NWGSALDRHA NFGFFWTGAL TLVRSSTGES FNLVMHDLYG WWWGINRLTC CPECGPMINS
TSPLKQESIR IPSTGAEIWR QIPMTSCGAT EPGMLIYLVF QVLMAYVVLS IMVGVILENF
ANVGSENKRI KMEDIEDFRE VWLKYDPKGT FIVPSHNLLA MLQQLREPLG IQGKTHGPTH
GSPGGHLTRA DMLKHLGELD IPDHGGYIHF LETLTALSNK HAGCALPLVP TTEKLLKANK
QAVLKGGSKL DPPKHSALTN YLVSLLQSRW RGYAMRIQGD EMLASDETAK LGTVKIKASQ
VAPLPPL
//
