ID A0A0M0JLL2_9EUKA Unreviewed; 1035 AA.
AC A0A0M0JLL2;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 22-FEB-2023, entry version 23.
DE SubName: Full=DNA mismatch repair protein msh6 {ECO:0000313|EMBL:KOO27227.1};
GN ORFNames=Ctob_008505 {ECO:0000313|EMBL:KOO27227.1};
OS Chrysochromulina tobinii.
OC Eukaryota; Haptista; Haptophyta; Prymnesiophyceae; Prymnesiales;
OC Chrysochromulinaceae; Chrysochromulina.
OX NCBI_TaxID=1460289 {ECO:0000313|EMBL:KOO27227.1, ECO:0000313|Proteomes:UP000037460};
RN [1] {ECO:0000313|Proteomes:UP000037460}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP291 {ECO:0000313|Proteomes:UP000037460};
RX PubMed=26397803; DOI=10.1371/journal.pgen.1005469;
RA Hovde B.T., Deodato C.R., Hunsperger H.M., Ryken S.A., Yost W., Jha R.K.,
RA Patterson J., Monnat R.J. Jr., Barlow S.B., Starkenburg S.R.,
RA Cattolico R.A.;
RT "Genome Sequence and Transcriptome Analyses of Chrysochromulina tobin:
RT Metabolic Tools for Enhanced Algal Fitness in the Prominent Order
RT Prymnesiales (Haptophyceae).";
RL PLoS Genet. 11:e1005469-e1005469(2015).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOO27227.1}.
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DR EMBL; JWZX01002743; KOO27227.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M0JLL2; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000037460; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756};
KW Reference proteome {ECO:0000313|Proteomes:UP000037460}.
FT DOMAIN 876..892
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 593..620
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1035 AA; 111880 MW; 720239486F248EBD CRC64;
MASPSDGRQP PTAQQAAAVY AEAAKGPGAP SASPGAEEKQ VSFKFLLPNQ KCDAQGKRPG
EPGYDKTTIR VKLAPGERFT PGQEQYWEIK KHHADCVICF KMGKFYELFE EDALLGHREL
DLAFMGKGAP HAGFPEAALP KYAQKLVELG YKVGVVEQME TPDQLKERNA QKARGVKKEQ
AVRRELCSII TKGTAFHRDE KSTYLLAVDE DIASRTLGVA FVDAATGHFH LGQVVDDEQH
GCLRTLLAQL RPDEIVINEQ SLSRDAYTLL RRAVPDGLFN PLPRTAFWAD KAACTKALEA
GKYFDKDTIG AAAGAAAAAD NDEEEEEAEV TGPEARWPRA LRQAADRTPC LALSAFGGCA
TYLKRLLLDR QLLSMGHVSP WVPTDADADA IGAGARHKGG SASLVLDAKA LENLEVFENS
SDRTATGTLF SIIDKCSSSF GRRALRAWLC APPRRVEDIL ERQQAVGALL ESAELRAKLA
KTLKKLPDLE RLLARVHAFS VTQTSNDATH YTDINRARLA ELIKTLEGFE ALHAGIEAAA
AQHVNEALRE GAPRLAQTIT MGDGFPDLRE LLRHFREAFD WAKAKAEGRV IPSKGADDDY
DAAKEALEEV EGEIGGILRQ WQKHFGDKSI ELWSAAGSPT EPFQLAVPET TLAKHGTPAG
FMQMSSKKGT LRFWTPELKA AVTRFLSAKD ALDATLATSA RRLYARFSSH FAHWHRAVHA
AAELDCLLSL SAVSGQPGMT RPVFVDDAPR PFLRIDQGVN ICVRAALDGA NCVPNDIRIG
AAAEAGDAAH AGASPLMLLV TGPNMGGKST LLRQACLTVL LAHLGCHVPA AACILTPVDR
IFTRVGANDA IMAGLSTFRV ELEETATILR HATEHSLVIL DELGRGTATF DGMAIAHATL
SHLITHVRCR SLFATHYHAL TREFEAPNAR VALYHMACAV DEASRAVTFL YSFAPGACHR
SHGVNVARLA GLPEAVLELA ASKSAELEEL LDERYAVQLA RRVLAAAADA GEGGTAGAFE
VLLQLWHEVK AAARS
//
