ID   A0A0M2GBT8_9ACTN        Unreviewed;       822 AA.
AC   A0A0M2GBT8;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
DE   Flags: Fragment;
GN   ORFNames=UK15_38940 {ECO:0000313|EMBL:KJK33562.1};
OS   Streptomyces variegatus.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=284040 {ECO:0000313|EMBL:KJK33562.1, ECO:0000313|Proteomes:UP000034786};
RN   [1] {ECO:0000313|Proteomes:UP000034786}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL B-16380 {ECO:0000313|Proteomes:UP000034786};
RA   Ju K.-S., Doroghazi J.R., Metcalf W.;
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KJK33562.1}.
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DR   EMBL; JYJH01000105; KJK33562.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0M2GBT8; -.
DR   STRING; 284040.UK15_38940; -.
DR   PATRIC; fig|284040.3.peg.1322; -.
DR   Proteomes; UP000034786; Unassembled WGS sequence.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:UniProt.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   CDD; cd08952; KR_1_SDR_x; 1.
DR   Gene3D; 3.30.70.3290; -; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   Gene3D; 6.10.140.1830; -; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 1.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR041618; PKS_DE.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF18369; PKS_DE; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   SMART; SM00822; PKS_KR; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SMART; SM01294; PKS_PP_betabranch; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR   PROSITE; PS50075; CARRIER; 1.
PE   4: Predicted;
KW   Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          697..772
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KJK33562.1"
FT   NON_TER         822
FT                   /evidence="ECO:0000313|EMBL:KJK33562.1"
SQ   SEQUENCE   822 AA;  86585 MW;  30DCC5A78AC63AFC CRC64;
     APRIPLVSNV TGGMATAEEL CDPGYWVRHV RAAVRFADGV GALAEQGVRT FVELGPDGVL
     SAMGQDSADA LFVPALRTDR PEAQTVTTAV TQAHVRGATV DWSAFFAGWG TRPVELPTYA
     FQRERYWTVS EPAGAGDRAD PVDQAFWDAV ERADVARVAE TLQVGAAERD SLSAVLPVLS
     AWRKRHRTES VVDSWRYRIT WKPLAEAAPT VPAGTWLAVV PEALRSDEWV DATLSAMDGR
     GARTVVLTVG SAEGDRAALA RRLTELVAEE GSVAGVLSFL ALDETARPQH PGVTAGLWST
     LELVRALGDA DATAPLWCLT RGAVSVGRSD RLASPAQAQA WGLGRVVGLE HPDRWGGLVD
     VPETADEPAL RRLLAVLAGS GDEDQIAVRA SGVFVRRLAH APRRTADGAP WRPRGTVLVT
     GGTGALGAEV ARWLARNGAE HLILTSRRGI EAPGAGELRR ELAGFGAEVT VAACDVADRE
     ALADLLAALP PERPLRAVVH AAGVGQYAPL AGMDADEFAR VVTGKVAGAR HLHELLLDTP
     LDAFVLFSSV SGIWGSGGQG AYAAANAYLD ALAQQRRDSG RPATALAWGP WAEVGLAAAD
     ATGEAQLRRG GLLPLAPESA IAALQQAMDA DDTALTIADV MWEQFLPGFA VARPRPLIGD
     LPAVRKVLDA ERPHDTGLAD SALARRLRGL SEADRGRALL ELVRSETAAV LGHASPDDVA
     AERPFKELGF DSLTAVEFRN RLNSATGLTL PSTLVYDFPT AAVLAERLGR ELRGAGAQST
     ADEPVVAAGA ADEPIAIVGM ACRYPGGVMS PEDLWRLVAE GG
//