ID A0A0M2GME1_9ACTN Unreviewed; 296 AA.
AC A0A0M2GME1;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Dihydrodipicolinate synthase {ECO:0000313|EMBL:KJK39237.1};
GN ORFNames=UK15_12190 {ECO:0000313|EMBL:KJK39237.1};
OS Streptomyces variegatus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=284040 {ECO:0000313|EMBL:KJK39237.1, ECO:0000313|Proteomes:UP000034786};
RN [1] {ECO:0000313|Proteomes:UP000034786}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL B-16380 {ECO:0000313|Proteomes:UP000034786};
RA Ju K.-S., Doroghazi J.R., Metcalf W.;
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DapA family.
CC {ECO:0000256|PIRNR:PIRNR001365}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJK39237.1}.
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DR EMBL; JYJH01000007; KJK39237.1; -; Genomic_DNA.
DR RefSeq; WP_031135005.1; NZ_JYJH01000007.1.
DR AlphaFoldDB; A0A0M2GME1; -.
DR STRING; 284040.UK15_12190; -.
DR PATRIC; fig|284040.3.peg.7123; -.
DR Proteomes; UP000034786; Unassembled WGS sequence.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR CDD; cd00408; DHDPS-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002220; DapA-like.
DR PANTHER; PTHR12128:SF74; BLL4423 PROTEIN; 1.
DR PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR Pfam; PF00701; DHDPS; 1.
DR PIRSF; PIRSF001365; DHDPS; 1.
DR PRINTS; PR00146; DHPICSNTHASE.
DR SMART; SM01130; DHDPS; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|PIRNR:PIRNR001365}.
FT ACT_SITE 136
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT ACT_SITE 164
FT /note="Schiff-base intermediate with substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT BINDING 205
FT /ligand="pyruvate"
FT /ligand_id="ChEBI:CHEBI:15361"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ SEQUENCE 296 AA; 31781 MW; 3878752B9CAB22A0 CRC64;
MTDHRPWRGV LVATALPLND DLSVNYDRYA EHCAWLVGNG CDGVVPNGSL GEYQVLTPEE
RARVVETAVA AIGGERVMPG VAAYGSAESR RWAEQAGEAG CRAVMLLPPN AYRADERSVL
AHYAEVARSG LPVVAYNNPI DTKVDLVPEL LARLHGEGHI RGVKEFSGDV RRAYRIAELA
PELDLLIGAD DVLLELAVAG AKGWVAGYPN ALPRASVELY RAAVGGDLDT ALPLYRQLHP
LLRWDSRVEF VQAIKLSMDV VGRHGGPCRP PRAALLPDQE AAVRAATEKA VAAGSS
//
