ID   A0A0M2JRV1_9MYCO        Unreviewed;       988 AA.
AC   A0A0M2JRV1;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Membrane protein {ECO:0000313|EMBL:KKE99699.1};
GN   ORFNames=WN67_22670 {ECO:0000313|EMBL:KKE99699.1};
OS   Mycolicibacterium obuense.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=1807 {ECO:0000313|EMBL:KKE99699.1, ECO:0000313|Proteomes:UP000034150};
RN   [1] {ECO:0000313|EMBL:KKE99699.1, ECO:0000313|Proteomes:UP000034150}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UC1 {ECO:0000313|EMBL:KKE99699.1,
RC   ECO:0000313|Proteomes:UP000034150};
RA   Greninger A.L., Cunningham G., Chiu C.Y., Miller S.;
RT   "Genome sequence of Mycobacterium obuense UC1.";
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KKE99699.1}.
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DR   EMBL; LAUZ02000093; KKE99699.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0M2JRV1; -.
DR   STRING; 1807.MOBUDSM44075_01607; -.
DR   PATRIC; fig|1807.13.peg.5238; -.
DR   Proteomes; UP000034150; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR004707; MmpL_fam.
DR   InterPro; IPR023908; xxxLxxG_rpt.
DR   NCBIfam; TIGR00833; actII; 1.
DR   NCBIfam; TIGR03057; xxxLxxG_by_4; 1.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..988
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5005634877"
FT   TRANSMEM        171..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        196..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        228..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        268..291
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        303..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        358..379
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        805..824
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        831..856
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        862..882
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        903..929
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          31..355
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
FT   DOMAIN          661..980
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
SQ   SEQUENCE   988 AA;  104607 MW;  819FA99834C88C75 CRC64;
     MIGVWLVLAV ALPPLFPSLA TVIQQQPTSP LPSDAPAIVA NRDIAQAFPS AGSDNTVLVL
     MTDEAGLDRA DEHTYRQLVG RLDRDSHDVV MLQEFIGTPE LRETLSSADG KAWIMPVGIR
     GELGSVESNE AYRRVADIVR NSVAGSDLTV HLTGPAATVA DFVGVNLRDQ ARIEAAIITF
     LLVILFVIYR NPITMLLPLI AIGVSLNIAG ALLAGASQFG LAVSSQTLVF LTGMLAGAGT
     DYAVFLISRY HDFLRRGADS DQALVNALGS IGKVIAASAA TVGVTFLGMS FARLDLFATT
     GPALAIAIAV AFLAAVTVLP AIMVLAGRRR WIAPRRDLTT RFWRRSGIRI VRRPRTNLIV
     SLAALLALAG CVGLVHYNYD DRLALPPNVE SSIGYAAMDK RFPLTSIIPQ YLFIQSPHDL
     RTPEALADME QMARRVSQLP DITAVRGITR PTGEPLEAAS TTAQAGEVGK RLSDASTLIE
     NRSADLNTLN DGAGQLADAL ASIRDQMAKS MSSVGSLLNM LTAIQKQLGQ LGGGATIGQV
     GDGDRLVSGM RSLGDTLQTV FGNVSNFDWI EPVVTALDGS EYCTTNPLCS AARDQFRAMA
     QARRDGTFDK LAGIARQLQA TGPLSNLSQT VRQLTSSMNA ATRSLGPLGL GGAGGGGAGS
     ITNLQQGFNR LADGSRQVAN GVDQLVDQTK RMGTDLGTAS EFLLAMKNEA TSPSMAGFYI
     PPQMLSSADF KKAARFFISA DGHSARYLVQ TTLNPFSTAA MDQVDAISAT ARGAQPNTAL
     ADATVRMTGY SATLSDARDY YDHDIRFIIA LTILVVLAIL VILLRAVVAP LYLIASVLLS
     YLAALGLGVV FFQFLLGQQL HWSVPGLTFI ILVAMGADYN MLLISRIRDE SPRGIRSGVI
     RTVGSTGGVI TAAGLIFAAS MFGLLFASIG TIVQAGFVVG TGILLDTFVV RTVTVPAMAV
     LVGRANWWPS RPKPASASPE PVPKEVPS
//