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Database: UniProt
Entry: A0A0M2JYP5_9MYCO
LinkDB: A0A0M2JYP5_9MYCO
Original site: A0A0M2JYP5_9MYCO 
ID   A0A0M2JYP5_9MYCO        Unreviewed;       489 AA.
AC   A0A0M2JYP5;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-SEP-2017, entry version 16.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=WN67_21400 {ECO:0000313|EMBL:KKE99957.1};
OS   Mycobacterium obuense.
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=1807 {ECO:0000313|EMBL:KKE99957.1, ECO:0000313|Proteomes:UP000034150};
RN   [1] {ECO:0000313|EMBL:KKE99957.1, ECO:0000313|Proteomes:UP000034150}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UC1 {ECO:0000313|EMBL:KKE99957.1,
RC   ECO:0000313|Proteomes:UP000034150};
RA   Greninger A.L., Cunningham G., Chiu C.Y., Miller S.;
RT   "Genome sequence of Mycobacterium obuense UC1.";
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KKE99957.1}.
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DR   EMBL; LAUZ02000024; KKE99957.1; -; Genomic_DNA.
DR   RefSeq; WP_046365070.1; NZ_LAUZ02000024.1.
DR   EnsemblBacteria; KKE99957; KKE99957; WN67_21400.
DR   PATRIC; fig|1807.13.peg.2503; -.
DR   Proteomes; UP000034150; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000034150};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000034150}.
FT   DOMAIN      182    310       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      394    462       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     190    197       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   489 AA;  54873 MW;  60455B32336AC5F5 CRC64;
     MSADPDPPFV SIWNNVVTEL NGERGSANGT LTPQQRAWLK LVQPLVITEG FALLSVPTPF
     VQNEIERHLR EPIIAALSRQ LGQRVELGVR IADPEPEATP ALAPVAVADS DDDLVDDDLA
     ARASAEENWP SFFANRGANA STDDATAINL NRRYTFDTFV IGASNRFAHA ASLAIAEAPA
     RAYNPLFIWG ESGLGKTHLL HAAGNYAQRL FPGMRVKYVS TEEFTNDFIN SLRDDRRASF
     KRTYRDIDVL LVDDIQFIEG KDGIQEEFFH TFNTLHNANK QIVISSDRPP KQLATLEDRL
     RTRFEWGLIT DVQPPELETR IAILRKKAQM DRLDVPDDVL ELIASRIERN IRELEGALIR
     VTAFASLNKT SIDKSLAEIV LRDLISDSST MQISTAAIMA ATAEYFETSI DELRGPGKTR
     ALAQSRQIAM YLCRELTDLS LPKIGQAFGR DHTTVMYAEK KIRGEMAERR EVFDHVKELT
     TRIRQRAKR
//
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