ID A0A0M2KC16_9GAMM Unreviewed; 458 AA.
AC A0A0M2KC16;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN Name=cpxA {ECO:0000313|EMBL:KKF36915.1};
GN ORFNames=AV903_22740 {ECO:0000313|EMBL:AXF78192.1}, SY86_18170
GN {ECO:0000313|EMBL:KKF36915.1};
OS Erwinia tracheiphila.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Erwiniaceae; Erwinia.
OX NCBI_TaxID=65700 {ECO:0000313|EMBL:KKF36915.1, ECO:0000313|Proteomes:UP000033924};
RN [1] {ECO:0000313|EMBL:KKF36915.1, ECO:0000313|Proteomes:UP000033924}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BuffGH {ECO:0000313|EMBL:KKF36915.1,
RC ECO:0000313|Proteomes:UP000033924};
RA Shapiro L.R.;
RT "Erwinia tracheiphila.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AXF78192.1, ECO:0000313|Proteomes:UP000264980}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MDcuke {ECO:0000313|EMBL:AXF78192.1,
RC ECO:0000313|Proteomes:UP000264980};
RA Oliw E.H.;
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CP013970; AXF78192.1; -; Genomic_DNA.
DR EMBL; JXNU01000003; KKF36915.1; -; Genomic_DNA.
DR RefSeq; WP_016191290.1; NZ_JXNU01000003.1.
DR AlphaFoldDB; A0A0M2KC16; -.
DR STRING; 65700.SY86_18170; -.
DR PATRIC; fig|65700.7.peg.4534; -.
DR Proteomes; UP000033924; Unassembled WGS sequence.
DR Proteomes; UP000264980; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd16949; HATPase_CpxA-like; 1.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.210; Two-component sensor protein CpxA, periplasmic domain; 1.
DR InterPro; IPR032404; CpxA_peri.
DR InterPro; IPR038515; CpxA_peri_sf.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR45528; SENSOR HISTIDINE KINASE CPXA; 1.
DR PANTHER; PTHR45528:SF12; SENSOR HISTIDINE KINASE CPXA; 1.
DR Pfam; PF16527; CpxA_peri; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AXF78192.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000033924};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 165..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 184..237
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 245..455
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 458 AA; 51843 MW; 3CDF151E9A381419 CRC64;
MISSLTTRIF AIFWLTLALV LMLVLMLPKL DTRQMTPLQD NEQRQGIMIE QHIEAELIQT
PPNDLMWWRR LFRVIDKWAP PGQRLLLVTS EGRVIGAQHN EMQVIRNFIG QSDNANHPKK
KKYGRTEMLG PFSVRDGEDN YQLYLIRPAG STQLDFINLL FDRPLLLLVV TMLISSPLLL
WLAWSLAKPA RKLKHAADDV AAGNLRQRPE LESGPQEFLA AGASFNQMVS ALERMMTSQQ
RLLSDISHEL RTPLTRLQLA TALMRRRQGE GKELQRIEME ALRLDGMIND LLVLSRTQHK
NALVSEAMKA SQLWSGVLDD AQFEAEQMGK TLDIPYPPGP WPLYGNPSAL DSALENIVRN
ALRYSYSKIM VSFSVDKRGI TVHVDDDGPG VSTEDREQIF RPFYRTDEAR DRESGGTGLG
LAIVETAIQQ HHGWVKADDS PLGGLRLTIW LPLYTSTS
//
