ID   A0A0M2U3V4_9FIRM        Unreviewed;       807 AA.
AC   A0A0M2U3V4;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:KKM10882.1};
GN   ORFNames=SY88_11345 {ECO:0000313|EMBL:KKM10882.1};
OS   Clostridiales bacterium PH28_bin88.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales.
OX   NCBI_TaxID=1605376 {ECO:0000313|EMBL:KKM10882.1, ECO:0000313|Proteomes:UP000034222};
RN   [1] {ECO:0000313|EMBL:KKM10882.1, ECO:0000313|Proteomes:UP000034222}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Robbins S., Tyson G.;
RT   "High quality genome sequence of Candidatus Suratobacter aromatica.";
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC         NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|ARBA:ARBA00023693};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00005005}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KKM10882.1}.
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DR   EMBL; LAKY01000047; KKM10882.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0M2U3V4; -.
DR   STRING; 1605376.SY88_11345; -.
DR   PATRIC; fig|1605376.3.peg.966; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000034222; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   CDD; cd06558; crotonase-like; 1.
DR   Gene3D; 1.10.1040.50; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000034222}.
FT   DOMAIN          8..205
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          208..307
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   807 AA;  89100 MW;  89C3ED867FE7AB59 CRC64;
     MRRDISKAMV LGSGVMGSTI AAHLANVGIP TYLLDIVPGE LTEEEKWKGL TLENPVVRNR
     LAARGKEGAL KARPAAFYVP ENADLVSVGN LEDNLSWASE VDWIIEVVVE RLDVKRDLFQ
     KLEAYRRPGT IVSSNTSGIS INAMAEGRSE DFRRHFLGTH FFNPPRYMRL LEVIPGRDTL
     PEVVEFMMGF GHRVLGKGVV LAKDTPNFVA NRIGVYGMVA TINAMVEDGL TVEQVDAITG
     PAMGRPKSAT YRTADLVGLD TFMHVARNVR DSLADPGEKR EFLTPEFLEE MLKNRWLGDK
     SGQGFYKKVK SEQGKEVLSL DYRTLEYRPQ QKAKFPSLEA AKAVEDLPKR LKGLVYAQDP
     AGKFAWKIMK KTLLYSAARV PEIADDIVNI DRGMKWGFNW ELGPFEAWDA IGVEESVARM
     RQEGETIPPL VEKLLAKGYK SFYRKEGGKT WYFDQESGEY QALSHVPDVI FLPDLKEQRR
     VVKSNAGASL VDLGDGVACL EFHSKSNAIG SDIVEMIRYS VEEVSKNFAG LVLGNHGKNF
     SVGANLVLIL LEAQDDNWED LDMMVRQFQG AAMALKHCPK PVVAAPFQMA LGGGCEMVLA
     AHRVQASAET YMGLVEVGVG LLPAGGGTKE MLLRAMERIP SQPGSQVPLN IDPTSFVARA
     FENIATAKVS TSGPDAQRLG YLRTTDGITI NPDRVIYEAK QAVLAIAREG FKPPQPAKVR
     VLGRQGYAGL DLMVYTLHQG GYISDYDAHI ARKIARVLSG GDVSPGTVVT EQYILDLERE
     NFLSLLGELR TQQRIQHMLA TGKPLRN
//