ID A0A0M2UXT9_9BACT Unreviewed; 773 AA.
AC A0A0M2UXT9;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=CRISPR-associated protein {ECO:0000313|EMBL:KKO19284.1};
GN ORFNames=BROFUL_01998 {ECO:0000313|EMBL:KKO19284.1};
OS Candidatus Brocadia fulgida.
OC Bacteria; Planctomycetota; Candidatus Brocadiia; Candidatus Brocadiales;
OC Candidatus Brocadiaceae; Brocadia.
OX NCBI_TaxID=380242 {ECO:0000313|EMBL:KKO19284.1, ECO:0000313|Proteomes:UP000034954};
RN [1] {ECO:0000313|EMBL:KKO19284.1, ECO:0000313|Proteomes:UP000034954}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RU1 {ECO:0000313|EMBL:KKO19284.1};
RX PubMed=24267221; DOI=10.1186/1471-2180-13-265;
RA Ferousi C., Speth D.R., Reimann J., Op den Camp H.J., Allen J.W.,
RA Keltjens J.T., Jetten M.S.;
RT "Identification of the type II cytochrome c maturation pathway in anammox
RT bacteria by comparative genomics.";
RL BMC Microbiol. 13:265-265(2013).
CC -!- SIMILARITY: In the N-terminal section; belongs to the CRISPR-associated
CC nuclease Cas3-HD family. {ECO:0000256|ARBA:ARBA00006847}.
CC -!- SIMILARITY: In the central section; belongs to the CRISPR-associated
CC helicase Cas3 family. {ECO:0000256|ARBA:ARBA00009046}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKO19284.1}.
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DR EMBL; LAQJ01000202; KKO19284.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M2UXT9; -.
DR PATRIC; fig|380242.3.peg.2489; -.
DR Proteomes; UP000034954; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR CDD; cd09641; Cas3''_I; 1.
DR CDD; cd17930; DEXHc_cas3; 1.
DR Gene3D; 1.10.3210.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006483; CRISPR-assoc_Cas3_HD.
DR InterPro; IPR038257; CRISPR-assoc_Cas3_HD_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR006474; Helicase_Cas3_CRISPR-ass_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01587; cas3_core; 1.
DR NCBIfam; TIGR01596; cas3_HD; 1.
DR Pfam; PF00270; DEAD; 1.
DR SMART; SM00487; DEXDc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51643; HD_CAS3; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000034954}.
FT DOMAIN 7..176
FT /note="HD Cas3-type"
FT /evidence="ECO:0000259|PROSITE:PS51643"
FT DOMAIN 254..447
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
SQ SEQUENCE 773 AA; 88709 MW; 45C9641F388DB063 CRC64;
MEEQQYFAHK KHLLSKHLKD VGTKASDFAS AFDASLHGKI AGLLHDLGKV EAEFQQRLES
DDKQVKNKKP HAHHGAMIAL KKDAWPIAFA INGHHSGLHN RSDVSKRKND YLNKAEAASN
LLHTSDQNWV CPDIAEILPK WLQDLEFDPT KTSEGWFAAE FFTRMLFSAL IDADRLDTEA
FEKMNDPSLE LRKWPEFKSD DLVQKLKKEL HARMEQAVKE QKASQEVLKV RNEVGRLAEQ
AARNERGLFS MSVPTGGGKT LASLLFALMH AKFHNDKIAP DDSKRFKRII VVIPYLSIIE
QTVSEFVKIF GEDMILEHHS QVDEKNASDY KKEKEDGEID FKAKRRRMAA ENWDSPIIVT
TSVQFFDSLF SRKPAQVRKL HNICQSVIIF DEVQTLPPLL LQPILNVLNE LTNPNRPYKC
SAVFCTATQP ALSKTEDLPC GIEGLVPIIP KETARGHFNV LKRTDYNWQD EKKSWDNIAN
EMLNAPMKQA LAVVNTRPNA RSLHEAAKNV IGQGSDYLFH LSTWMMPSHR RTVLDEVKNR
IKNHQPCILV STQCIEAGVD VDFPEVWRAF GPYDSIVQAA GRCNRNGKLD RGKVHVFIPS
DKGLSKGLYF TATKQTELLR KMNLADPENP ETFEHYFRLL YQLSVPDECG IQKARAEFRF
EEVDKLFNFI DEKTIPVLIL RERIGDKEHD TEAKQVYDIA QKRGFFLRDD WRTLQKYMMN
LPYHYLSTSP YRENIISVFD DKLNLYLWNG IYRGGICGYG LEFNGLTIEE MTQ
//
