ID A0A0M3HQA3_ASCLU Unreviewed; 461 AA.
AC A0A0M3HQA3;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=EGF-like domain-containing protein {ECO:0000313|WBParaSite:ALUE_0000424001-mRNA-1};
OS Ascaris lumbricoides (Giant roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Ascaris.
OX NCBI_TaxID=6252 {ECO:0000313|Proteomes:UP000036681, ECO:0000313|WBParaSite:ALUE_0000424001-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:ALUE_0000424001-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A0M3HQA3; -.
DR WBParaSite; ALUE_0000424001-mRNA-1; ALUE_0000424001-mRNA-1; ALUE_0000424001.
DR Proteomes; UP000036681; Unplaced.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 2.40.128.20; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR InterPro; IPR012674; Calycin.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR003582; ShKT_dom.
DR InterPro; IPR014878; THAP4-like_heme-bd.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF01549; ShK; 1.
DR Pfam; PF08768; THAP4_heme-bd; 1.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00254; ShKT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF50814; Lipocalins; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS51670; SHKT; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 85..124
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 125..160
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 161..196
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 198..234
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 237..274
FT /note="ShKT"
FT /evidence="ECO:0000259|PROSITE:PS51670"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 114..123
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 129..139
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 150..159
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 186..195
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 224..233
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 461 AA; 51840 MW; 9AF2890E917EBFBE CRC64;
MRQFKTDFDQ LDRESHALTS ARSTSGALTS LKTLQPSDET PAPQNFLKRP VSQAVINTPL
SIPINTEPDL KSADNMKAKP TQKPDIAACS NNPCMNGGTC LKDRRKQDGF RCDCAVGWTG
KKCDEMDHCL NHECVSGECI NNSDNYTCEC LPNFAGQFCT RDCGIDFCKR NGTCIEKRGG
ELACECPPGS AGKHCEREIN ECNFRRCKNA IKCIDKWNDY ECICEPGWMG KNCDRPCQDI
YGSCKLWKRQ GQCELMRDHT NFFDSNCALS CGQCEFINST IRSTRPMPSA LLPLAWMLGI
WRTDVNGTRN RVIDYPLDFR SNGYEETLMI SLEVPLMFGT PSINFTSIAI SKTDPEDQHV
LQGFVTIRNR PDEAQLVALS SVSNLGVMMI EEGELHGSSV TLKPRYRVTH PLIHDVMPKD
MSRSFLKNGE KLLQSVSKKN ADGKNEHISK HYKKIVHIEY L
//
