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Database: UniProt
Entry: A0A0M3HSB2_ASCLU
LinkDB: A0A0M3HSB2_ASCLU
Original site: A0A0M3HSB2_ASCLU 
ID   A0A0M3HSB2_ASCLU        Unreviewed;       928 AA.
AC   A0A0M3HSB2;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 2.
DT   15-FEB-2017, entry version 8.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Ascaris lumbricoides (Giant roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Ascaridida;
OC   Ascaridoidea; Ascarididae; Ascaris.
OX   NCBI_TaxID=6252 {ECO:0000313|Proteomes:UP000036681, ECO:0000313|WBParaSite:ALUE_0000533201-mRNA-1};
RN   [1] {ECO:0000313|Proteomes:UP000036681, ECO:0000313|WBParaSite:ALUE_0000533201-mRNA-1}
RP   NUCLEOTIDE SEQUENCE.
RG   Helminth Genomes Consortium;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:ALUE_0000533201-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (MAY-2016) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   WBParaSite; ALUE_0000533201-mRNA-1; ALUE_0000533201-mRNA-1; ALUE_0000533201.
DR   Proteomes; UP000036681; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000036681};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000036681};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    442    466       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    487    505       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    585    605       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    617    642       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    654    674       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    717    739       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    843    862       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    868    892       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   928 AA;  106623 MW;  3EC053F3D878939E CRC64;
     MGVRDFDTTL SLQQFDVHSE PHDIYSTVIE STRLITMGSL YRSEQMRFCQ MIVQKDAAFA
     CVAELGKHPY VQFKDLNADV NPFQRMFVRD IRRFDELERK LRFIDTQIRK DNIEIVDESK
     DGVYEVIPPH ELNQLEATLV DLERDVISMN ESDLILKRNF LELKEWEAIL EKADQFFQGG
     ISDVAMQEIE AVQEEEIGFP LRSDKEPMGF TTGVINRERV NAFERILWRA CRRTAFVRTA
     EIEEELIDPD NGEKLSKSVF VIFYKGDRLR TIIEKVCEGF KAKLYNTCPK NSKDRHAAAR
     EARARISDLG TVMGQTHEHR YKVLKAASAN VREWQKQVRM QKSVYHTLNL FTFDSIGKFF
     VAECWVPLDD MQNVRDALER GVEVNGISVK PVLNLLETAE EPPTYNKINK FTAVFQAIVD
     SYGIASYLEV NPAPYTIITF PFIFACMFGD LGHGLLMFFA GLFLVLREKN LIARNIKDEI
     FNMFFGGRYI ILLMGIFSIY AGLLYNDAFA KSFNIFGSSW RNPFRKSEIE SWYNQSVLTH
     KDVLIELPPN PSFLHGYGPY PFGVDPVWNL AENKLNFLNS MKMKLSVIIG ISQMTFGVFL
     SLMNFTFFKS KIEIFTVFIP QLLFMFCIFI YLCIEIIVKW IFFWVEEMHI FGRLYPGSHC
     APSLLIGLIN MFMFKEREAG FVNMSQIVRK EGPRIIYAEY PSCYLAQWYP AQSTVEACLV
     IVAVICVPVM LFGKPLYVLS QQKKAKEAMG DKMIVRVSMQ NEETEIASNG DGQGQGNGHI
     EKDQRKSTDE SETNVHHDEE SFGDIMVHQA IHTIEYVLGC VSHTASYLRL WALSLAHAQL
     SEVLWHMVLV QAFALSGVAG YFASYFIFVA FGILTVSILV LMEGLSAFLH ALRLHWVEFQ
     SKFYLGLGYQ FVPFYFKDVL DKASVSDN
//
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