ID A0A0M3I8S6_ASCLU Unreviewed; 1215 AA.
AC A0A0M3I8S6;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 2.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Eukaryotic translation initiation factor 5B {ECO:0000256|ARBA:ARBA00013824};
DE AltName: Full=Translation initiation factor IF-2 {ECO:0000256|ARBA:ARBA00032478};
OS Ascaris lumbricoides (Giant roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Ascaris.
OX NCBI_TaxID=6252 {ECO:0000313|Proteomes:UP000036681, ECO:0000313|WBParaSite:ALUE_0001378001-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:ALUE_0001378001-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (MAY-2016) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007733}.
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DR WBParaSite; ALUE_0001378001-mRNA-1; ALUE_0001378001-mRNA-1; ALUE_0001378001.
DR Proteomes; UP000036681; Unplaced.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd03703; aeIF5B_II; 1.
DR CDD; cd16266; IF2_aeIF5B_IV; 1.
DR CDD; cd01887; IF2_eIF5B; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR InterPro; IPR029459; EFTU-type.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43381:SF4; EUKARYOTIC TRANSLATION INITIATION FACTOR 5B; 1.
DR PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF14578; GTP_EFTU_D4; 1.
DR Pfam; PF11987; IF-2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917}.
FT DOMAIN 640..862
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 1..615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 964..1023
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 15..59
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..118
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..256
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..302
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..422
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..486
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..519
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 527..574
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..602
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1215 AA; 136829 MW; 42749D0E821E40F9 CRC64;
MQKYSQFVIF QLGSDDESTD KESASDSANE KPVEKVAVPT RKEQKKGKEA KKDESSDQVA
KETNATVKAK ETGKGKAKKG KKSAKEDEDL DALLADLDKP IERPIGKGKK KGAAKEEPTR
ETNTAAVVEP EITPAFEAGD LDAHHQGDAK AEEEGDAAAK KKDKKKKKKK GGAEKEKSEE
PVTTQEVQRE LALQEDKGEQ PNEQEAMKEE QLDGEXVRIN EAFEDSKKRD KEAGDLDAHQ
QEDAKAEEEG DAATKKKEKK KKKKKGGAEK EKSEEPVTTQ EVQGELALQE DKGEQPNEEE
AMKEEQLDGE AAEGGEESAA DKKKEKKKKK EKEKKAKEGD KKETKKKKHV DLIKQLLREK
QEAEERLLRE QREEEERLAA IQRAKEEEER LAREKKEREK QRKKERDERL KAEGKYLTPA
QKEKLRKQQA MLASMNVILP AALREGGQES APAKRPVYGK KKQRRGQQQE NKGSTPDSSA
QPSEVPSREI SVEPKKPKIE EEKVADSWDD LIVDEKPQEV PDDWEQESEE RYEKLENESE
KVTAPNEERN ATAEVKKTST DVREVPRVEK EDEAESSSEG ESEESSSEEE SSEEEEEESS
EDEQTTRESK EQLKERVRAR LKANFKRKEA AEAKRTVDDL RAPVICVLGH VDTGKTKMLD
TIRRTNVQDG EAGGITQQIG ATQVPAAAIK ERTKMVREFD GDKMKIPGFL IIDTPGHESF
SNLRSRGSSL CDYAILVVDL MHGLEQQTLE SLKLLRKRET PFVIALNKID RLYDYESNPR
KDVYQHLKSQ PINAQLQFKE LKDKVVLQFA EQFAEQGVNV ALANENPDPN EYVSMVPTSA
FLGDGIGNLM AYIVIESQTR LARKLAFCEE LECIVMEVKS LPGLGTTIDV ILVNGTLRVG
DVIVLTGTEG AIMTQIRELL MPQPLRELRV KNAYEHFQSI KAAQGVKILA KGLEKALAGL
PIFVANKEDE LDVLKEESEA QLSKALMAIK KKPEGVYVQA STLGSLEALL EFLKKAAAML
ERKEEYACIL AFDVRVDRDA EQFAATEGVR IFSADIIYHL EESFLKYREE LRLRRRRENE
HLAIFPCKLR ILPQHVFNAR NPIVVGVSVE AGQLKRGTPL CVPSKDCIFI GTVSSIERNH
EQVDLAKTGD EVCVKIENTT GEAPKLYGRH FNHEDALVSR ISRETIDVCK AHFRDDLSKA
DWQLIVQLKK LLDIM
//