ID   A0A0M3IB31_ASCLU        Unreviewed;       467 AA.
AC   A0A0M3IB31;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   RecName: Full=Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial {ECO:0000256|ARBA:ARBA00019998};
OS   Ascaris lumbricoides (Giant roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Ascaris.
OX   NCBI_TaxID=6252 {ECO:0000313|Proteomes:UP000036681, ECO:0000313|WBParaSite:ALUE_0001485901-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:ALUE_0001485901-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Mitochondrion {ECO:0000256|ARBA:ARBA00004173}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the ECSIT family.
CC       {ECO:0000256|ARBA:ARBA00007674}.
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DR   AlphaFoldDB; A0A0M3IB31; -.
DR   WBParaSite; ALUE_0001485901-mRNA-1; ALUE_0001485901-mRNA-1; ALUE_0001485901.
DR   Proteomes; UP000036681; Unplaced.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR029342; ECIST_C.
DR   InterPro; IPR010418; ECSIT.
DR   InterPro; IPR046448; ECSIT_N.
DR   PANTHER; PTHR13113; ECSIT EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAYS; 1.
DR   PANTHER; PTHR13113:SF1; EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAY, MITOCHONDRIAL; 1.
DR   Pfam; PF14784; ECSIT_C; 1.
DR   Pfam; PF06239; ECSIT_N; 2.
DR   SMART; SM01284; ECSIT_Cterm; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT   DOMAIN          323..447
FT                   /note="ECSIT C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01284"
SQ   SEQUENCE   467 AA;  54716 MW;  DD45473912B2C67B CRC64;
     MKRFTHLLEL HALHKQIYAQ SELLWRHASS SSSRGEKRSN NPSETRLQHI DEHFESIPPE
     QRNKRTFNAA IDLFRLKKTQ TRGHVEFINS ALKYLKEYGL HKDLDTYKAI LNVFPKGAMI
     PRNTFQKIFL HYPMQQNCCI KVLDQMEWFD LFRLKKTQTR GHVEFINSAL KYLEEYGLHK
     DLDTYKAILN VFPKGAMIPR NTFQKIFLHY PMQQNCCIKV LDQMEWFGVQ PDKEVHDIVA
     NAFGEWNFAT KKIKRMLYWM PKLKHSNKYL DRRSIEGREV GAVELAFIAL KMMARDPGTA
     FSYVTVKDCE LPESERWMVS AQSVLQQRLL DERKAKSTLY VNGPSKVHVM DRIVEYVWLT
     ADPDPENYFD NFRPDSEDDD NFEEWHSNWE HGGTRRKQQN IHQQRDETIL GLAVLAKTSD
     QTAAAWINHL TETNPNIKQL RVLFRLKRPI SDLPVPEFGG TVSGPCS
//