ID A0A0M3JV09_ANISI Unreviewed; 726 AA.
AC A0A0M3JV09;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=[heparan sulfate]-glucosamine N-sulfotransferase {ECO:0000256|ARBA:ARBA00012979};
DE EC=2.8.2.8 {ECO:0000256|ARBA:ARBA00012979};
GN ORFNames=ASIM_LOCUS11509 {ECO:0000313|EMBL:VDK45230.1};
OS Anisakis simplex (Herring worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Anisakidae; Anisakis;
OC Anisakis simplex complex.
OX NCBI_TaxID=6269 {ECO:0000313|Proteomes:UP000036680, ECO:0000313|WBParaSite:ASIM_0001204301-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:ASIM_0001204301-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDK45230.1, ECO:0000313|Proteomes:UP000267096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Glycan metabolism; heparan sulfate biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005093}.
CC -!- PATHWAY: Glycan metabolism; heparin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004841}.
CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family. NDST subfamily.
CC {ECO:0000256|ARBA:ARBA00010420}.
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DR EMBL; UYRR01031077; VDK45230.1; -; Genomic_DNA.
DR WBParaSite; ASIM_0001204301-mRNA-1; ASIM_0001204301-mRNA-1; ASIM_0001204301.
DR UniPathway; UPA00756; -.
DR UniPathway; UPA00862; -.
DR Proteomes; UP000036680; Unplaced.
DR Proteomes; UP000267096; Unassembled WGS sequence.
DR GO; GO:0015016; F:[heparan sulfate]-glucosamine N-sulfotransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0030210; P:heparin biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR021930; Heparan_SO4_deacetylase.
DR InterPro; IPR037359; NST/OST.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR10605:SF56; BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE_N-SULFOTRANSFERASE; 1.
DR PANTHER; PTHR10605; HEPARAN SULFATE SULFOTRANSFERASE; 1.
DR Pfam; PF12062; HSNSD; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000267096}.
FT DOMAIN 42..459
FT /note="Heparan sulphate-N-deacetylase"
FT /evidence="ECO:0000259|Pfam:PF12062"
FT DOMAIN 552..646
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
FT ACT_SITE 561
FT /note="For sulfotransferase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-1"
SQ SEQUENCE 726 AA; 83210 MW; 41455CB6E77E9888 CRC64;
YPPQRLPPYV CPKGNDTART FGFDKKLAIK SQRVPNVAWK SDAKILVFVE TVYSKLGKQI
LSVLDALKVT YKVETLSKNL PLLTTAKRGR FSMIVIENYY KYLNLPAWNR QLLDKYCLDY
GVGIISFISS RTSVSYVQAK IKDSPLQFRQ KQHAANLRFS PDSSVNFLAK PGAILETPQP
DLDDWILFNV SEGFDSIISA DDELGFERAA VIHDRGYFDG IERILFGHNF THWINKISFV
DSLRYMSGGS LQLDLKRYIE IDVDDIFVGQ SGSRMTAADA DALLESQNRL RHSVENFTYC
LGFSGSFFRN GDSLEVKGDE RLIEVGQNFI WFPHMWRHNH VHELNITQIK ALMTLNKMFA
QSWKIPVTSQ YAISPQHAGV YPVHEDLFDA WREIWNISVT STEEYPHFRP SSSRRGFIYK
NISVLPRQTC GLYTHTHFFH SYPDGLSTLI NNIEGGDLFL TILLNPFSIF MTHQQNFAND
RLGIFTFERV IEFIKCWTNL RLYWMEPVRI AEAYFRRFPN ERTPVWSNPC ADARHEKILP
KAFDCSAPMP LPNLLIVGPQ KTGSTALSTY LSLHPNCTTN DPVPSSFEEL QFFGGSNYAR
GILWYMDKFA RKVKPEQHSV VFEKSATYFD NSEAPRAAST LLPKANVILL VVMGIDSGGL
GTNRCLGPSK GRQYEPIDER TRTRLNELFL EDNIALHKLL IRNDLPIPEW LRSQLSKPRT
NDHDYP
//
