ID A0A0M3JV58_ANISI Unreviewed; 653 AA.
AC A0A0M3JV58;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Neuroendocrine convertase 2 (inferred by orthology to a human protein) {ECO:0000313|WBParaSite:ASIM_0001209801-mRNA-1};
GN ORFNames=ASIM_LOCUS11564 {ECO:0000313|EMBL:VDK45352.1};
OS Anisakis simplex (Herring worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Anisakidae; Anisakis;
OC Anisakis simplex complex.
OX NCBI_TaxID=6269 {ECO:0000313|Proteomes:UP000036680, ECO:0000313|WBParaSite:ASIM_0001209801-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:ASIM_0001209801-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDK45352.1, ECO:0000313|Proteomes:UP000267096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S8 family. Furin subfamily.
CC {ECO:0000256|ARBA:ARBA00005325}.
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DR EMBL; UYRR01031082; VDK45352.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M3JV58; -.
DR WBParaSite; ASIM_0001209801-mRNA-1; ASIM_0001209801-mRNA-1; ASIM_0001209801.
DR Proteomes; UP000036680; Unplaced.
DR Proteomes; UP000267096; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016486; P:peptide hormone processing; IEA:UniProt.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.30.70.850; Peptidase S8, pro-domain; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR032815; S8_pro-domain.
DR InterPro; IPR038466; S8_pro-domain_sf.
DR PANTHER; PTHR42884:SF13; NEUROENDOCRINE CONVERTASE 2; 1.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF16470; S8_pro-domain; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000267096};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}.
FT DOMAIN 494..624
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT ACT_SITE 177
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 218
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 393
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 653 AA; 71878 MW; 3E22813F2F16E1A3 CRC64;
MSENGARNIQ NIFVFIITAL CALGDTLEVY TNHFHVHTKV PGAENAHKIA KRHGFINRGP
VLGSATEWHF VQPALSHART KRSTVHQMLL KNDDDIAHVE QLTGYKRTKR GYRALEERLQ
EQLDFSSVQS PTDPLYPYQW YLKNVGQAGG KKRLDLNVEK AWALGFTGKN VTTAIMDDGV
DYMHPDIKNN FNAKASYDFS SNDPFPYPRY TDDWFNSHGT RCAGEIAAAR DNGVCGVGVA
YDSKVAGIRM LDQPYMTDLI EANSMGHEPN LIHIYSASWG PTDDGKTVDG PRNATMRAIV
KGVNEGRNGL GSIFVWASGD GGEDDDCNCD GYAASMWTIS INSAINSGEN AHYDESCSST
LASTFSNGGR NPETGVATTD LYGRCTRSHS GTSAAAPEAA GVFALALEAN PQLTWRDLQH
LTVLTSSRNS LFDGRCRDLP DLGLEGDEMH NKETKNCSHF EWQMNGIGLE YNHLFGFGVL
DAAEMVMLAV VWKPSPPRFH CEAGTINTPH EIPASGNLIL DLDTDSCAGT NTEVNYLEHV
QAVVTLNSSR RGDTTLYLIS PAGTRRPKDD DSKDGFTNWP FMTTHTWGEN PRGRWRLVAR
FQGPGAHHGT VKKFTLMLHG TKDPPYVGIE PLQGHVNSKL SVVQKAHKRA AVF
//
