ID A0A0M3UH70_9MICC Unreviewed; 364 AA.
AC A0A0M3UH70;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Pyruvate dehydrogenase {ECO:0000313|EMBL:ALE93959.1};
GN ORFNames=AOC05_03610 {ECO:0000313|EMBL:ALE93959.1};
OS Arthrobacter alpinus.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Arthrobacter.
OX NCBI_TaxID=656366 {ECO:0000313|EMBL:ALE93959.1, ECO:0000313|Proteomes:UP000062833};
RN [1] {ECO:0000313|Proteomes:UP000062833}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R3.8 {ECO:0000313|Proteomes:UP000062833};
RA See-Too W.S., Chan K.G.;
RT "Complete genome of Arthrobacter alpinus strain R3.8.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR EMBL; CP012677; ALE93959.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M3UH70; -.
DR KEGG; aaq:AOC05_03610; -.
DR PATRIC; fig|656366.3.peg.787; -.
DR Proteomes; UP000062833; Chromosome.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR017596; PdhA/BkdA.
DR InterPro; IPR029061; THDP-binding.
DR NCBIfam; TIGR03181; PDH_E1_alph_x; 1.
DR PANTHER; PTHR43380; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43380:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Pyruvate {ECO:0000313|EMBL:ALE93959.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000062833}.
FT DOMAIN 36..304
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
SQ SEQUENCE 364 AA; 39264 MW; B6FA6226F8DCF21C CRC64;
MHQLIGADGT SVVDELLAPF VTDVDDDQLL ELLSDMVVIR RIDAEATALQ RQGQLALWPP
MLGQEAAQIG SVRALEDDDF IFPTYRENGV AYCRGAKLAG IMSTWRGSAN TGWDPYEFNM
ATPQIIIGAQ TLHATGYAMG LTMDGKESLA IAYLGDGATS QGDVHESMVF AASFQAPVVF
FCQNNHWAIS EPVGLQSHVP LAGRAPGYGI PSLRVDGNDV LAVLAATRWA ATRARSGGGP
SFIEAVTYRM GAHTTADDPT RYRGVTELEE WRGKDPIARL RAFLQGRGKL DAGQEAALEA
KADAVAAELR AGCINMPDPA PMSIFDNVYT SGHAILDRQR DHYERYLASF SGTEVDALAE
GNRS
//
