ID A0A0M3UHF3_9MICC Unreviewed; 426 AA.
AC A0A0M3UHF3;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=DNA polymerase {ECO:0000313|EMBL:ALE94379.1};
GN ORFNames=AOC05_17935 {ECO:0000313|EMBL:ALE94379.1};
OS Arthrobacter alpinus.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Arthrobacter.
OX NCBI_TaxID=656366 {ECO:0000313|EMBL:ALE94379.1, ECO:0000313|Proteomes:UP000062833};
RN [1] {ECO:0000313|Proteomes:UP000062833}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R3.8 {ECO:0000313|Proteomes:UP000062833};
RA See-Too W.S., Chan K.G.;
RT "Complete genome of Arthrobacter alpinus strain R3.8.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Poorly processive, error-prone DNA polymerase involved in
CC untargeted mutagenesis. Copies undamaged DNA at stalled replication
CC forks, which arise in vivo from mismatched or misaligned primer ends.
CC These misaligned primers can be extended by PolIV. Exhibits no 3'-5'
CC exonuclease (proofreading) activity. May be involved in translesional
CC synthesis, in conjunction with the beta clamp from PolIII.
CC {ECO:0000256|ARBA:ARBA00025589}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-Y family.
CC {ECO:0000256|ARBA:ARBA00010945}.
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DR EMBL; CP012677; ALE94379.1; -; Genomic_DNA.
DR RefSeq; WP_062010016.1; NZ_CP012677.1.
DR AlphaFoldDB; A0A0M3UHF3; -.
DR KEGG; aaq:AOC05_17935; -.
DR PATRIC; fig|656366.3.peg.3859; -.
DR OrthoDB; 9808813at2; -.
DR Proteomes; UP000062833; Chromosome.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-KW.
DR CDD; cd01700; PolY_Pol_V_umuC; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.1170.60; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR InterPro; IPR025188; DUF4113.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR11076; DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER; 1.
DR PANTHER; PTHR11076:SF34; PROTEIN UMUC; 1.
DR Pfam; PF13438; DUF4113; 1.
DR Pfam; PF00817; IMS; 1.
DR Pfam; PF11799; IMS_C; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50173; UMUC; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00023199};
KW Reference proteome {ECO:0000313|Proteomes:UP000062833};
KW SOS mutagenesis {ECO:0000256|ARBA:ARBA00023199};
KW SOS response {ECO:0000256|ARBA:ARBA00023236}.
FT DOMAIN 7..192
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
SQ SEQUENCE 426 AA; 46628 MW; 95908690679AFA63 CRC64;
MPGSDYIAHV DVNSFYASAE RAFNPSLEGV PVVVLSNNDG CVVTRTAEAK ALGIPMGEPW
FKIAPRAKAW GLVALSSNYE LYGDISSRVM ELLGRYSAWV EVYSIDEAFL GVNGTPIQIR
KLGRTIKDAV RRHVGVPVCV GIARTKGLAK LANKLAKHNP DFAGVCHWES IPEDVREGLM
SRLSVVELWG VAARLTKRLN AMGIHTILDL KNTNPVLIRD RFSVVLMRTV LELQGTACIP
MEEERVGRDQ LIFSRSFSTP VTTAADMGQV MSVYAQQASA RLAKHGLQAK VLTAFAGTSN
YNQDSISYPS VCVPLPLPTA DPVLLHRAAN SLCERIYEGV KYVRAGIMVT DLRPTGNQSP
LELFENPHEE RGIGPLLEAV SKRYGRGSIG LGSAGVRGGP DWSMKREMLS PRYTTHWDEL
LLVKAS
//