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Database: UniProt
Entry: A0A0M4M8E7_9ACTN
LinkDB: A0A0M4M8E7_9ACTN
Original site: A0A0M4M8E7_9ACTN 
ID   A0A0M4M8E7_9ACTN        Unreviewed;       581 AA.
AC   A0A0M4M8E7;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   05-JUL-2017, entry version 16.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=AL705_04625 {ECO:0000313|EMBL:ALE19026.1};
OS   Lawsonella clevelandensis.
OC   Bacteria; Actinobacteria; Corynebacteriales; Lawsonella.
OX   NCBI_TaxID=1528099 {ECO:0000313|EMBL:ALE19026.1, ECO:0000313|Proteomes:UP000068137};
RN   [1] {ECO:0000313|EMBL:ALE19026.1, ECO:0000313|Proteomes:UP000068137}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=X1698 {ECO:0000313|EMBL:ALE19026.1,
RC   ECO:0000313|Proteomes:UP000068137};
RX   PubMed=26659691;
RA   Nicholson A.C., Bell M., Humrighouse B.W., McQuiston J.R.;
RT   "Complete Genome Sequences for Two Strains of a Novel Fastidious,
RT   Partially Acid-Fast, Gram-Positive Corynebacterineae Bacterium,
RT   Derived from Human Clinical Samples.";
RL   Genome Announc. 3:e01462-15(2015).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP012390; ALE19026.1; -; Genomic_DNA.
DR   RefSeq; WP_053962019.1; NZ_CP012390.1.
DR   EnsemblBacteria; ALE19026; ALE19026; AL705_04625.
DR   KEGG; cbq:AL705_04625; -.
DR   PATRIC; fig|1562462.4.peg.949; -.
DR   KO; K02313; -.
DR   Proteomes; UP000068137; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000068137};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000068137}.
FT   DOMAIN      271    399       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      483    552       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     279    286       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   581 AA;  64682 MW;  4D4AD51F28C547A0 CRC64;
     MVTQTQDLHH IWGQVLDELE TASANPYSTS PSLSPQQRAW LKLVEPIQYT NGFALLSAPN
     TFAKEAIERT LHEPITCALE KFLGEEVTLA VKVIEKTPAT SADPNDSHVL LREALNANPV
     TGPWPRPPVV AQDRILPEDI PTYRPENIAT PITRPQFPQG DAPATPDTAS TPPASTVATD
     AQRAATQFTP TPPTSTEPTH TQSEATTDLD ADRPQQDVTQ KPPPPTATAP AEATPTPTLN
     PRYTFDNYVV GDSNRFATAA AWAISEAPAH AYNPLFIWGG SGLGKTHLLH AIGHYTHQLF
     PRLKVRYVST EEFTNDFINS LRDDRKEKFK KRYRDCDLLL VDDIQFIEGK EGIQEEFFYT
     FEALHNSNKQ IVISSDRPPA LLSTLEDRLR TRFEWGLITD IQAPDLETRT AILRKKAQVE
     KLQVPNEVLE LIASRIDRNI RELEGALIRV TAFASLNKQP LTPELAQVVL RDLVPADKQV
     QVTAATIMTV VAEAYSTSVD ELCGPSKTRP LATARQIAMY LCRELTEMSL PKIGSTFGGR
     DHTTVMYAER KISKQIKDDR TVFTQVQQLT SNIKKRAELD Q
//
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