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Database: UniProt
Entry: A0A0M4RCB2_9PSEU
LinkDB: A0A0M4RCB2_9PSEU
Original site: A0A0M4RCB2_9PSEU 
ID   A0A0M4RCB2_9PSEU        Unreviewed;       585 AA.
AC   A0A0M4RCB2;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   05-JUL-2017, entry version 17.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=XF36_25480 {ECO:0000313|EMBL:ALE86076.1};
OS   Pseudonocardia sp. HH130629-09.
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Pseudonocardia.
OX   NCBI_TaxID=1641402 {ECO:0000313|EMBL:ALE86076.1, ECO:0000313|Proteomes:UP000062082};
RN   [1] {ECO:0000313|EMBL:ALE86076.1, ECO:0000313|Proteomes:UP000062082}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HH130629-09 {ECO:0000313|EMBL:ALE86076.1,
RC   ECO:0000313|Proteomes:UP000062082};
RX   PubMed=26438860; DOI=10.1073/pnas.1515348112;
RA   Sit C.S., Van Arnam E.B., Ramadhar T.R.;
RT   "Variable genetic architectures produce virtually identical molecules
RT   in bacterial symbionts of fungus-growing ants.";
RL   Proc. Natl. Acad. Sci. U.S.A. 112:13150-13154(2015).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP011868; ALE86076.1; -; Genomic_DNA.
DR   RefSeq; WP_060713929.1; NZ_CP011868.1.
DR   EnsemblBacteria; ALE86076; ALE86076; XF36_25480.
DR   KEGG; pseh:XF36_25480; -.
DR   PATRIC; fig|1641402.3.peg.5457; -.
DR   KO; K02313; -.
DR   Proteomes; UP000062082; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000062082};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000062082}.
FT   DOMAIN      277    405       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      489    558       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     285    292       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   585 AA;  63332 MW;  E7A487D2A0DCFE30 CRC64;
     MTDQPGDLGA VWNRVIADLS GASAESGTPT LSPQQRAFLR LTRPLGLLDG TALLAAPSEF
     AKDAIERILR RPISDALGRH LGVAVNLAVV VDASAASGGT EVPDPPGFGM HRGVTAGDSV
     RDTGTGDRAG DATGAVATGD HGTGAAPEHV AHEHVDGAGP DTGPQPAVDS GHGNGFAGGS
     RRDDAGPSGT DRGWSAEQPP SSSGGWAPQP GGRPEPGSRD GQTSWPAYTA PQAGDPVAPR
     SQTRLNERYT FDTFVIGASN RFSHAAAVAV AEAPARAYNP LFIWGESGLG KTHLLHAVGH
     YAQRLFPGMR VRYVSTEEFT NDFINSLRDD RKVAFQRRYR DVDVLLVDDI QFLEGKEGTQ
     EEFFHTFNTL HNANKQIVVS SDRPPKRLET LEDRMRTRFE WGLITDIQPP ELETRIAILR
     KKAAQDRLAV PGEVLEFIAE RIERNIRELE GALIRVTAFA SLNRQAVDTQ LAEIVLRDLI
     PDSAASEITA PTIMAVTAEF FGLTLDELSG PGKTKALAQA RQIAMYLCRE LTDLSLPRIG
     QTFGGRDHTT VMHADKKIRN EISLRRKTFE QVQELTARIK LRARH
//
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