ID A0A0M6YEK2_9RHOB Unreviewed; 291 AA.
AC A0A0M6YEK2;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=2-hydroxy-3-oxopropionate reductase {ECO:0000313|EMBL:CTQ48758.1};
DE EC=1.1.1.60 {ECO:0000313|EMBL:CTQ48758.1};
GN Name=garR_2 {ECO:0000313|EMBL:CTQ48758.1};
GN ORFNames=JDO7802_00763 {ECO:0000313|EMBL:CTQ48758.1};
OS Jannaschia donghaensis.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Jannaschia.
OX NCBI_TaxID=420998 {ECO:0000313|EMBL:CTQ48758.1, ECO:0000313|Proteomes:UP000049222};
RN [1] {ECO:0000313|EMBL:CTQ48758.1, ECO:0000313|Proteomes:UP000049222}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CECT 7802 {ECO:0000313|EMBL:CTQ48758.1,
RC ECO:0000313|Proteomes:UP000049222};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CXSU01000005; CTQ48758.1; -; Genomic_DNA.
DR RefSeq; WP_055082695.1; NZ_CXSU01000005.1.
DR AlphaFoldDB; A0A0M6YEK2; -.
DR STRING; 420998.JDO7802_00763; -.
DR OrthoDB; 9812907at2; -.
DR Proteomes; UP000049222; Unassembled WGS sequence.
DR GO; GO:0008679; F:2-hydroxy-3-oxopropionate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000313|EMBL:CTQ48758.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000049222};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..291
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005807941"
FT DOMAIN 3..160
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 166..283
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 172
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 291 AA; 30056 MW; 1D7D124C9CC67AB8 CRC64;
MANVAFLGMG VMGAPMAGHL AAAGHFVQVY NRTEAKAEAW VGKHGGAAAS TPHAAALGCD
IVMACVGNDD DLRSVCLGGD GAFAGMAKGS IFVDHTTVSA EVTRELAAAA ADRGIAWVDA
PVSGGQAGAE NGQLVIMCGG AQADYDRVEP VMACFAKLTK RMGDVGAGQL TKMVNQICIA
GLMQGLSEAM TFAQKAGLDG EAVVDVIQGG AAGSWQMVNR HKTMLAGEYD HGFAVDWMRK
DLSICLAEAE NIGAPLPGTA LIDQYYKDVQ AMGGGRWDTS SLMARLVKLS E
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