ID A0A0M8P0G3_9EURO Unreviewed; 862 AA.
AC A0A0M8P0G3;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Beta-mannosidase B {ECO:0000256|ARBA:ARBA00041069};
DE EC=3.2.1.25 {ECO:0000256|ARBA:ARBA00012754};
DE AltName: Full=Mannanase B {ECO:0000256|ARBA:ARBA00041614};
GN ORFNames=ACN38_g6124 {ECO:0000313|EMBL:KOS42976.1};
OS Penicillium nordicum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=229535 {ECO:0000313|EMBL:KOS42976.1, ECO:0000313|Proteomes:UP000037696};
RN [1] {ECO:0000313|EMBL:KOS42976.1, ECO:0000313|Proteomes:UP000037696}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DAOMC 185683 {ECO:0000313|EMBL:KOS42976.1,
RC ECO:0000313|Proteomes:UP000037696};
RA Nguyen H.D., Seifert K.A.;
RT "Genome sequencing of Penicillium nordicum.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal, non-reducing beta-D-mannose residues
CC in beta-D-mannosides.; EC=3.2.1.25;
CC Evidence={ECO:0000256|ARBA:ARBA00000829};
CC -!- PATHWAY: Glycan metabolism; N-glycan degradation.
CC {ECO:0000256|ARBA:ARBA00004740}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family. Beta-
CC mannosidase B subfamily. {ECO:0000256|ARBA:ARBA00038429}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOS42976.1}.
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DR EMBL; LHQQ01000092; KOS42976.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M8P0G3; -.
DR STRING; 229535.A0A0M8P0G3; -.
DR OrthoDB; 2504097at2759; -.
DR UniPathway; UPA00280; -.
DR Proteomes; UP000037696; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004567; F:beta-mannosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR041625; Beta-mannosidase_Ig.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR041447; Mannosidase_ig.
DR PANTHER; PTHR43730; BETA-MANNOSIDASE; 1.
DR PANTHER; PTHR43730:SF1; BETA-MANNOSIDASE; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF17753; Ig_mannosidase; 1.
DR Pfam; PF17786; Mannosidase_ig; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 2.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000037696};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 193..299
FT /note="Glycoside hydrolase family 2 immunoglobulin-like
FT beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF00703"
FT DOMAIN 681..777
FT /note="Mannosidase Ig/CBM-like"
FT /evidence="ECO:0000259|Pfam:PF17786"
FT DOMAIN 785..837
FT /note="Beta-mannosidase Ig-fold"
FT /evidence="ECO:0000259|Pfam:PF17753"
SQ SEQUENCE 862 AA; 98389 MW; F1C6B77D712A6494 CRC64;
MQKFMRELKT GWSLKQAGDV SNECWIPVKK VPSQVHIDLI ANKKIPDPFV DANELAVQWI
AEKDWVYRTK FTAPSSEGTT TDLIFLGLDT FATVTLNGTT ILESENMHTS HRVNISELLR
AGQENDLQIV FQSALLRGRE LVDQHPEHIF HVRQTEASRI PVRKAQYNWG WDWGPILMAA
GPWRPVVLEQ YTARIDDVWT QYEISADNKS CSGTLYARVG AGTQEGDTVI LSLFNADQAV
FEQKCHIGAD GVAKAAVQLA SPSLWYPHGY GSQFRYRLSA CLIRRNTRLD EQTKLVGFRW
CQLVQEKDEF GKSFYFRING IDVFGGGSCW IPADSYLAQV SKHRYLDWMK LMVESNQIMI
RVWGGGIYED DAFMESCDTL GILVWHDFAF VCASYPVYPR FLKSIEEEVR QNIRRLRSHP
SLVIWAGNNE DYQVQERYKL EYNQDDTDAE SWRQSTFPAR YIYEHLLPKW VQEEDPSCIY
HPGSPWGDGK HTTDPTVGDI HQWNIWHGKM SRYQDSANLG GRFVSEFGME AYPHLESLRR
VITDPQQQHP GSMMMDFRNK AADHERRLMI YVAENFIVPS DLASFTHVTQ VLQAETMRYA
YKAWRRNWGQ PGARRCGGVL VWQLNDCWPT MSWAIVDYYL VKKPAFYAIS RALRPLDVGI
SRSCPVWTSG HADSMSTNSC EFDLWVASSL QEAVEVQIKT RFISIRSGKL VSETIDITTV
ATPNSTTEIL EKHRVKVSMT CEDGDYKNLD PFIIHAELYV EGLLEAADTV WPQPLKYLDF
ANRNVRVEGS PSQGEITVSA DLPVKGFVFE EIEGLKLSDN GFDLIPGEKK RITLSGKGVT
TMELPWTYVG AKPLQLGKNP KL
//
