ID A0A0M8QLA2_9ACTN Unreviewed; 334 AA.
AC A0A0M8QLA2;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=2-oxoisovalerate dehydrogenase {ECO:0000313|EMBL:KOT32549.1};
GN ORFNames=ADK41_28960 {ECO:0000313|EMBL:KOT32549.1};
OS Streptomyces caelestis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=36816 {ECO:0000313|EMBL:KOT32549.1, ECO:0000313|Proteomes:UP000037773};
RN [1] {ECO:0000313|EMBL:KOT32549.1, ECO:0000313|Proteomes:UP000037773}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL B-24567 {ECO:0000313|EMBL:KOT32549.1,
RC ECO:0000313|Proteomes:UP000037773};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOT32549.1}.
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DR EMBL; LGCN01000228; KOT32549.1; -; Genomic_DNA.
DR RefSeq; WP_030819987.1; NZ_LGCN01000228.1.
DR AlphaFoldDB; A0A0M8QLA2; -.
DR PATRIC; fig|36816.3.peg.6275; -.
DR OrthoDB; 3457658at2; -.
DR Proteomes; UP000037773; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR CDD; cd07036; TPP_PYR_E1-PDHc-beta_like; 1.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR InterPro; IPR033248; Transketolase_C.
DR PANTHER; PTHR42980:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL; 1.
DR PANTHER; PTHR42980; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED; 1.
DR Pfam; PF02779; Transket_pyr; 1.
DR Pfam; PF02780; Transketolase_C; 1.
DR SMART; SM00861; Transket_pyr; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000037773}.
FT DOMAIN 9..184
FT /note="Transketolase-like pyrimidine-binding"
FT /evidence="ECO:0000259|SMART:SM00861"
SQ SEQUENCE 334 AA; 35854 MW; 66ED68C94412A74E CRC64;
MTTVAVKPAT MAQALTRALR DAMAADPSVH VMGEDVGTLG GVFRVTDGLA EEFGADRCTD
TPLAEAGILG TAVGMAMYGL RPVVEMQFDA FAYPAFEQLV SHVAKTRNRT RGRMPLPLTV
RVPYGGGIGG VEHHSDSSEA YYMATPGLHV VTPATVADAY GLLRAAIASD DPVVFLEPKR
LYWSKDAWNP EEPTAVEPIG RAVVRRSGRS ATLITYGPSL PVCMEAAEAA RAEGWDLEVV
DLRSLVPFDD ETVCASVRRT GRAVVVHESG GFGGPGGEIA ARVTERCFHH LEAPVLRVAG
FDLPYPPPML ERHHLPGVDR ILDAVGRLQW EAES
//