ID   A0A0M8TFN1_9ACTN        Unreviewed;       248 AA.
AC   A0A0M8TFN1;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=2-oxoacid dehydrogenase acyltransferase catalytic domain-containing protein {ECO:0000259|Pfam:PF00198};
GN   ORFNames=ADK57_38495 {ECO:0000313|EMBL:KOU57593.1};
OS   Streptomyces sp. MMG1533.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1415546 {ECO:0000313|EMBL:KOU57593.1, ECO:0000313|Proteomes:UP000037741};
RN   [1] {ECO:0000313|Proteomes:UP000037741}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MMG1533 {ECO:0000313|Proteomes:UP000037741};
RA   Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC         Evidence={ECO:0000256|ARBA:ARBA00001938};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KOU57593.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LGDG01000260; KOU57593.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0M8TFN1; -.
DR   STRING; 1415546.ADK57_38495; -.
DR   PATRIC; fig|1415546.3.peg.8301; -.
DR   Proteomes; UP000037741; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   PANTHER; PTHR43178; DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX; 1.
DR   PANTHER; PTHR43178:SF5; LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL; 1.
DR   Pfam; PF00198; 2-oxoacid_dh; 2.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000037741};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        158..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          14..113
FT                   /note="2-oxoacid dehydrogenase acyltransferase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00198"
FT   DOMAIN          155..240
FT                   /note="2-oxoacid dehydrogenase acyltransferase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00198"
SQ   SEQUENCE   248 AA;  27047 MW;  F7121D77716A9D03 CRC64;
     MVVAAERAGR RMAAMHALVE LDVTTSRNLL TTSDRPMSFT AFVVASVARA AAAHPDAHAY
     RDWRGRLVRH QHVDVTTLVE VATEHGPFAL PHVLRDADTR DVRDLTAELR AVKADHSVTG
     TGRMLDHFGT TLTRVPGLVE AMYAVLARSV RLRQRTGTIA VTAVGMFGAA GGFGIAPLTL
     MPLQVVVGGM TWRPRVVDGR IEAREVLDLT VTFDHNVIDG APAARFMADL RRLIENAELL
     RTDDDEQA
//