ID A0A0M8THX6_9ACTN Unreviewed; 308 AA.
AC A0A0M8THX6;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Sphingosine kinase {ECO:0000313|EMBL:KOU57659.1};
GN ORFNames=ADK57_38235 {ECO:0000313|EMBL:KOU57659.1};
OS Streptomyces sp. MMG1533.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1415546 {ECO:0000313|EMBL:KOU57659.1, ECO:0000313|Proteomes:UP000037741};
RN [1] {ECO:0000313|Proteomes:UP000037741}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MMG1533 {ECO:0000313|Proteomes:UP000037741};
RA Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOU57659.1}.
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DR EMBL; LGDG01000259; KOU57659.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M8THX6; -.
DR STRING; 1415546.ADK57_38235; -.
DR PATRIC; fig|1415546.3.peg.8247; -.
DR Proteomes; UP000037741; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008654; P:phospholipid biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 2.60.200.40; -; 1.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR005218; Diacylglycerol/lipid_kinase.
DR InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR InterPro; IPR045540; YegS/DAGK_C.
DR NCBIfam; TIGR00147; YegS/Rv2252/BmrU family lipid kinase; 1.
DR PANTHER; PTHR12358:SF106; LIPID KINASE YEGS; 1.
DR PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR Pfam; PF00781; DAGK_cat; 1.
DR Pfam; PF19279; YegS_C; 1.
DR SMART; SM00046; DAGKc; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR PROSITE; PS50146; DAGK; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KOU57659.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000037741};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 12..147
FT /note="DAGKc"
FT /evidence="ECO:0000259|PROSITE:PS50146"
SQ SEQUENCE 308 AA; 31768 MW; 42FE33B8875FCB38 CRC64;
MIVRAALVTS GGVTSEITLF VNPTAGRGRG AHAAQPAASA LRAAGFSVRT VLGANAEDAL
TRARAAVAEG TAALIAVGGD GMANLALQAV AGTRTPLGLV AVGTGNDFAR ALGLPVRDPA
AAGRLIADAL KGARMHEVDL GQVDGRWFGT VLASGFDSRV NDRGNRMRWP AGRLKYDLAM
LAELAAFKPF RYRITLDDGD VREVEATLVA VGNGSSYGGG MRICPGADLT DGLFDITVVG
DCSRATLLRV FPTVYRGRHV EHSKVTVLRA AKVEIAAEGI TGYADGEALG PLPLTARCVP
AAVRIVGP
//
