ID   A0A0M8VIS1_9ACTN        Unreviewed;       308 AA.
AC   A0A0M8VIS1;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   SubName: Full=Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha {ECO:0000313|EMBL:KOV66811.1};
GN   ORFNames=ADL01_25530 {ECO:0000313|EMBL:KOV66811.1};
OS   Streptomyces sp. NRRL WC-3618.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1519490 {ECO:0000313|EMBL:KOV66811.1, ECO:0000313|Proteomes:UP000037738};
RN   [1] {ECO:0000313|EMBL:KOV66811.1, ECO:0000313|Proteomes:UP000037738}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL WC-3618 {ECO:0000313|EMBL:KOV66811.1,
RC   ECO:0000313|Proteomes:UP000037738};
RA   Noorani M.;
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KOV66811.1}.
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DR   EMBL; LGDW01000348; KOV66811.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0M8VIS1; -.
DR   PATRIC; fig|1519490.3.peg.5577; -.
DR   OrthoDB; 9766715at2; -.
DR   Proteomes; UP000037738; Unassembled WGS sequence.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR   GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR   CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR029061; THDP-binding.
DR   PANTHER; PTHR11516:SF60; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR11516; PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000037738}.
FT   DOMAIN          1..298
FT                   /note="Dehydrogenase E1 component"
FT                   /evidence="ECO:0000259|Pfam:PF00676"
SQ   SEQUENCE   308 AA;  32979 MW;  5C4137ED7A2B472B CRC64;
     MVRIRLFETE AGKLMEAGKL PGFLHLYVGQ EAVAAGVMTA LRDDDQITST HRGHGHAVAK
     GVGFREMYSE LYGRVTGACL GRGGSMHIND LTRGMLGANG IVGAGVPIAV GAAFAARYKG
     EDSVAVTFFG DGATNIGAWH EGANMAAILG LPVVFVCENN GYAEFTPQSA HMLITDVADR
     AAAYGMPSVI VDGMDAVAVH RAATEAVERA RRGEGPMMIE AKTYRFFDHQ GVKGLRHPYR
     SDEEVAEWKT RDPIDLIEAR AVADGTATRA ELDDVWQRTR DEIAEAIAYA EASPLPDPAD
     LLLNVYSG
//