ID A0A0M8WTC5_9ACTN Unreviewed; 881 AA.
AC A0A0M8WTC5;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=HTH luxR-type domain-containing protein {ECO:0000259|PROSITE:PS50043};
GN ORFNames=ADL04_30835 {ECO:0000313|EMBL:KOV92279.1};
OS Streptomyces sp. NRRL B-3648.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1519493 {ECO:0000313|EMBL:KOV92279.1, ECO:0000313|Proteomes:UP000037702};
RN [1] {ECO:0000313|EMBL:KOV92279.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL B-3648 {ECO:0000313|EMBL:KOV92279.1};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOV92279.1}.
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DR EMBL; LGDZ01000216; KOV92279.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M8WTC5; -.
DR PATRIC; fig|1519493.3.peg.6562; -.
DR Proteomes; UP000037702; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd06170; LuxR_C_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR PANTHER; PTHR16305:SF35; TRANSCRIPTIONAL ACTIVATOR DOMAIN; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF00196; GerE; 1.
DR PRINTS; PR00038; HTHLUXR.
DR SMART; SM00421; HTH_LUXR; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00622; HTH_LUXR_1; 1.
DR PROSITE; PS50043; HTH_LUXR_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000037702}.
FT DOMAIN 816..881
FT /note="HTH luxR-type"
FT /evidence="ECO:0000259|PROSITE:PS50043"
FT REGION 322..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..346
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 881 AA; 93175 MW; 22898B2027630156 CRC64;
MIAAAASGRG GAVVVRGEAG IGKTTLLRHV LDAQDGLRVL WVNGAEFEAD FAYAAVHQLT
RPLHDRIGRL PARQGNDLSV AFGLGEGSAP SQFAVALGVL GLLSEAAGES PVVCVVDDAQ
WLDRASAQVL AFAARRIGAE PIALVFGLRD PHGVDALDGL PELKLSGLSD QAARDLLASG
VPVPLDDRVR ERILAEARGN PLALLELPRR LGPAGLAGGF GLPTPASPAN RIEQSYRERV
SRLSPGARML LLIAASEPLG DPGLLWRAAD LLDVKPEAGT EAEAEELIEL GGRSRFRHPL
VRSAVYAAAS PADRRLVHGA LADVTDPQTD PDRRSWHRSQ AAPRPDEDVA ADLLRSAERA
RRRGGAAAEA AFLQQAASLT PDPRFRAKRS LAAARAALEA GAFETAITLV DAAEHGPIDD
AGRVEAELAR GQAAFFRDGA ADAVGHLIRA AGLDPGRARL YLLDALQAGL VVGRSSPACR
TALQAARQAP VPPGHRTGAD DLLDTLVAYL DGDLATVSVL SRMLSDTTDP LWSRRLSLAA
LLAVELWDFA LEERFATQAV TAARSSGALM ILPVGLWMRA MAAAQRGALL DASALLGEAD
GIAEVTGVPV HWYGHLQVAA VRGRPAEARP LIDRVLAESR ARRKGMLTAM AHSAAAFYAN
GVADHRAALE SATLALTDGD LSMSSMALPE LVEAAVRCGQ DAVAREAFAR LDEHTRAAGT
DWALGVRAAL GALLSDEPEA LHTEAVARLG AGGMRIWHGR ALLHQGAWLR RDGRRRESLE
ALRAAHDLFT TTGAEGFAER ARAELAAAGE QARSVTRGVL EALTGQELNI ARLVATGATS
REVADRLFLS PRTIDAHLRN IFKKLDITSR RQLADLVTQT I
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