ID A0A0M8WXG6_9ACTN Unreviewed; 428 AA.
AC A0A0M8WXG6;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=L-lysine N6-monooxygenase MbtG {ECO:0000256|ARBA:ARBA00016406};
DE EC=1.14.13.59 {ECO:0000256|ARBA:ARBA00013076};
DE AltName: Full=Lysine 6-N-hydroxylase {ECO:0000256|ARBA:ARBA00032738};
DE AltName: Full=Lysine N6-hydroxylase {ECO:0000256|ARBA:ARBA00032493};
DE AltName: Full=Lysine-N-oxygenase {ECO:0000256|ARBA:ARBA00029939};
DE AltName: Full=Mycobactin synthase protein G {ECO:0000256|ARBA:ARBA00031158};
GN ORFNames=ADL04_24940 {ECO:0000313|EMBL:KOV94360.1};
OS Streptomyces sp. NRRL B-3648.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1519493 {ECO:0000313|EMBL:KOV94360.1, ECO:0000313|Proteomes:UP000037702};
RN [1] {ECO:0000313|EMBL:KOV94360.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL B-3648 {ECO:0000313|EMBL:KOV94360.1};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+);
CC Xref=Rhea:RHEA:23228, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:32551, ChEBI:CHEBI:57783, ChEBI:CHEBI:57820,
CC ChEBI:CHEBI:58349; EC=1.14.13.59;
CC Evidence={ECO:0000256|ARBA:ARBA00000168};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: Siderophore biosynthesis. {ECO:0000256|ARBA:ARBA00004924}.
CC -!- SIMILARITY: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-
CC oxygenase family. {ECO:0000256|ARBA:ARBA00007588}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOV94360.1}.
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DR EMBL; LGDZ01000197; KOV94360.1; -; Genomic_DNA.
DR RefSeq; WP_053710495.1; NZ_LGDZ01000197.1.
DR AlphaFoldDB; A0A0M8WXG6; -.
DR PATRIC; fig|1519493.3.peg.5286; -.
DR OrthoDB; 7527071at2; -.
DR Proteomes; UP000037702; Unassembled WGS sequence.
DR GO; GO:0047091; F:L-lysine 6-monooxygenase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR025700; Lys/Orn_oxygenase.
DR PANTHER; PTHR42802:SF1; L-ORNITHINE N(5)-MONOOXYGENASE; 1.
DR PANTHER; PTHR42802; MONOOXYGENASE; 1.
DR Pfam; PF13434; Lys_Orn_oxgnase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000037702}.
SQ SEQUENCE 428 AA; 48626 MW; F598234F9826118E CRC64;
MTARPEAPHR THDFVGIGLG PFNLGLACLT EPIAELDGVF LESKPDFEWH AGMFLDGAHL
QTPFMSDLVT LADPTSPYSF LNYLKEKGRL YSFYIRENFY PLRVEYDDYC RWAAAQLSSV
RFGTTVTEVT YEDELYVVRT GAGDVYRARH LVLGTGTAPF VPEACRELGG DFLHTSRYMH
RKAELLKKKS VTIVGSGQSA AEIYFELLSG IDVHGYQLNW VTRSPRFFPL EYTKLTLEMT
SPDYVDYFRA LPEETRYRLE KQQKGLFKGI NSDLVDSIYD LLYQKDVESG DRPVPTRLLT
NSTLRTAAYR DGTYTLGFHQ DEQGKDFEIR TEGLVLATGY HYTPPAFLDP VRDRLLFDGH
GRFDVARNYA VDVTGRGVFL QNAGVHTHSI TSPDLGMGAY RNAYIIRELL GTEYYPVEKT
IAFQEFAV
//
