ID A0A0M8XB12_9ACTN Unreviewed; 645 AA.
AC A0A0M8XB12;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Succinate dehydrogenase {ECO:0000313|EMBL:KOX02118.1};
DE EC=1.3.5.1 {ECO:0000313|EMBL:KOX02118.1};
GN Name=sdhA {ECO:0000313|EMBL:KOX02118.1};
GN ORFNames=ADL04_13050 {ECO:0000313|EMBL:KOX02118.1};
OS Streptomyces sp. NRRL B-3648.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1519493 {ECO:0000313|EMBL:KOX02118.1, ECO:0000313|Proteomes:UP000037702};
RN [1] {ECO:0000313|EMBL:KOX02118.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL B-3648 {ECO:0000313|EMBL:KOX02118.1};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOX02118.1}.
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DR EMBL; LGDZ01000130; KOX02118.1; -; Genomic_DNA.
DR RefSeq; WP_053708856.1; NZ_LGDZ01000130.1.
DR AlphaFoldDB; A0A0M8XB12; -.
DR PATRIC; fig|1519493.3.peg.2801; -.
DR OrthoDB; 9805351at2; -.
DR Proteomes; UP000037702; Unassembled WGS sequence.
DR GO; GO:0102040; F:fumarate reductase (menaquinone); IEA:UniProtKB-EC.
DR GO; GO:0033765; F:steroid dehydrogenase activity, acting on the CH-CH group of donors; IEA:UniProt.
DR GO; GO:0008177; F:succinate dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 1.20.58.100; Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain; 1.
DR Gene3D; 3.90.700.10; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
DR InterPro; IPR003953; FAD-binding_2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR037099; Fum_R/Succ_DH_flav-like_C_sf.
DR InterPro; IPR015939; Fum_Rdtase/Succ_DH_flav-like_C.
DR InterPro; IPR030664; SdhA/FrdA/AprA.
DR InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR PANTHER; PTHR11632; SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT; 1.
DR PANTHER; PTHR11632:SF89; SUCCINATE DEHYDROGENASE [IRON-SULFUR SUBUNIT] (SUCCINIC DEHYDROGENASE)-RELATED; 1.
DR Pfam; PF00890; FAD_binding_2; 1.
DR Pfam; PF02910; Succ_DH_flav_C; 1.
DR PIRSF; PIRSF000171; SDHA_APRA_LASPO; 1.
DR PRINTS; PR00368; FADPNR.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF46977; Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain; 1.
DR SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
PE 4: Predicted;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:KOX02118.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000037702}.
FT DOMAIN 10..430
FT /note="FAD-dependent oxidoreductase 2 FAD binding"
FT /evidence="ECO:0000259|Pfam:PF00890"
FT DOMAIN 494..591
FT /note="Fumarate reductase/succinate dehydrogenase
FT flavoprotein-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02910"
FT REGION 302..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 322
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000171-1"
SQ SEQUENCE 645 AA; 71235 MW; 91ECE2FBD1A6B124 CRC64;
MSVVDRQEWD VVVVGAGGAG LRAAIEARER GARTAVICKS LFGKAHTVMA EGGIAAAMAN
ANEHDNWQVH FRDTLRGGKF LNQWRMAELH AQEAPERVWE LETWGALFDR TKDGRISQRN
FGGHEYPRLA HVGDRTGLEL IRTLQQKTVA LQQEDFKETG DYESRLKVFQ ECTVTRILKD
GDRVSGVFAY ERESGRFFVL EAPAVVVATG GIGKSFKVTS NSWEYTGDGH ALALLAGAPL
LNMEFVQFHP TGMVWPPSVK GILVTESVRG DGGVLRNSEG KRFMFDYVPD VFKEKYAESE
EEADRWYEDP DHNRRPPELL PRDEVARAIN AEVKAGRGSP HGGVFLDVST RMPAEVIRRR
LPSMYHQFKE LADVDITAEA MEVGPTCHYV MGGIAVDSDT AAARGVPGLY AAGEVAGGMH
GSNRLGGNSL SDLLVFGRRA GWHAAEYARG LAGRRPPVDE TQVDTAAAEA LRPFSAEAEG
DGAAGPPENP YTLHQELQQA MNDLVGIIRR EGEMEQALHR LAELRTRARR AGVEGHRQFN
PGWHLALDLR NMLLVSECVA RSALERTESR GGHTREDHPA MDRAWRNVNL LCTLADPSGG
LAATDPARGQ IRLARETTAP VRPDLLALFE KEELVKYFAE EELYE
//
