ID A0A0M8YM11_9ACTN Unreviewed; 1689 AA.
AC A0A0M8YM11;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KOX33962.1};
DE Flags: Fragment;
GN ORFNames=ADL06_08225 {ECO:0000313|EMBL:KOX33962.1};
OS Streptomyces sp. NRRL F-6491.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1519495 {ECO:0000313|EMBL:KOX33962.1, ECO:0000313|Proteomes:UP000037743};
RN [1] {ECO:0000313|EMBL:KOX33962.1, ECO:0000313|Proteomes:UP000037743}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL F-6491 {ECO:0000313|EMBL:KOX33962.1,
RC ECO:0000313|Proteomes:UP000037743};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOX33962.1}.
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DR EMBL; LGEE01000063; KOX33962.1; -; Genomic_DNA.
DR PATRIC; fig|1519495.3.peg.1738; -.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000037743; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd08956; KR_3_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..80
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1324..1399
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1417..1689
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 84..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 908..933
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KOX33962.1"
FT NON_TER 1689
FT /evidence="ECO:0000313|EMBL:KOX33962.1"
SQ SEQUENCE 1689 AA; 174173 MW; 5DF31F38F25ED3C1 CRC64;
GHAQAAAGVG GVIKTVMALR AGVLPKTLHA REPSPFVEWE GSGVRLLGEQ ETWPERGRPR
RAGVSSFGIS GTNSHVILEQ APEHDDHVGP AQPGPTADEP GAVSERPAPP VLLSGNTPAA
LRRQAAALAD HLRAHPDTDA HALAAALARR ARHAHGAAVP FDGDGDPDRL SAALRALADG
EVHDALITGE RAAGRTVFVF PGQGSQWSGM ARELLDASPV FRDGIEACAA ALAPHTDWSL
LDVLRGAPDA PGLDRVDVVQ PVLFAVMVSL AGLWRSAGVV PDAVVGHSQG EIAAAYVAGA
LSLADAAKLV ALRSRALTGI AGDSGMVSVA LDADALAPVL AEHPDELEIA VRNGPRATVV
AGGDTALGAL LAWCEEHGVR ARRIPVDYAS HTRYVEPLRE HLLELGAGLT PGTAGTAFYS
AVTGGPVATD TLDAGYWYRN LRETVRFEAA VDSLVDSGHR RFVEVSPHPV LTFAVEEILA
GRGVAAFTGG TLRRDHGGPD TFRRSLAAAH LGGAPVAWDV PATAPDLPLT YRFAPDRHWL
VPSGGPAATA LPGLTAEPHP LLGARVELAD GAAVFTGRID LRALPWLTDH GVFGTVLVPG
TAFAELALHA GAAVDLPAVA DLTVRAPLVP DPDRPTALQV RVAPVDATGA RELTVHARPD
DTAPWTLHAS ATLRAAAPAA TPAFPAFPPA DAAPVALDDV YAGLFRLGYD YGPAFQGLAA
ARRTPDGVLH AELDPGLSDG DGDASGTGFA LHPALLDAAL HPVVAGLVGT HAADPERPLL
PFAFEGLRIT DAAAAAAADR LRVRIEPLAD TRFRLTLADA HGNPVAEIDS LAFRPVGRAE
LAGRPAVGAT AHHLDWPELP LAGPATGTHL VLAGLGDTGL VTDAETVPDT EALSARATPP
TAVLVPVTGT VPPTGTAIGT GTAEGTGTGP DPRAVPARAH ELTAAVLALL QRWIATPAWD
GVPLHVVIRT GDLAAAPVRG LLRTAAAEHP GRFALVETDG PAPAARLAGD HGEPESALRD
GRVHVPRLAA HDLAPASPPA PDGAGTVLVT GGTGALGALV ARRLAARPNP PHLLLVSRTG
PAAPGAADLT AELRAAGAGT TVAACDVTDR DALARLLADV PADRPLRAVV HTAGVLADAT
VTELTPEQLA AALRPKVDAA WLLHELTAEL PLDAFVLFSS AVAVAGVPGQ ANYAAGNTFL
DALAAHRRDL GLPGVSLAWG LWEETGAMTG HLGAADRTRL ARYGVGPVAT EAGLDALFAA
ERPHTIVSPL DEGLLRQEAA AGRLRPVFGA LVRVPASAAR RAAGAGGGAW ADRLAAVPAH
ERLRTVTALL REQAALVLGH DGSDGIGADR PFKDLGFDSL TAVELRNRLG RLTGLTLPAT
VVFEYPTIAG LAGHLHASLT TDAPEEAAAV VRQRDVEDPV VIVGMGCRFP GGVASPEDLW
RLVADGTDAT GGFPEDRGWD LEKLYDPDPD HKGTTYTRRG GFLYDAAEFD ADFFGMSPRE
ALATDPQQRL LLQITWEALE RAGIDPHSLK DSDTGVFIGA MYDDYAARLR TAPEDVEGLL
LAGNQSSVAS GRIAYVLGLR GPALTVDTAC SSSLVALDLA VRAVRSGECA TALAGGVAVM
ATPSTFVEFS RQRGLSADGR CRAFGADADG TGWAEGAGIL VVERLSRARR EGHRVLAVVA
GSAVNQDGA
//
