ID A0A0M8ZU25_9HYME Unreviewed; 1286 AA.
AC A0A0M8ZU25;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Protein son of sevenless {ECO:0000313|EMBL:KOX69519.1};
DE Flags: Fragment;
GN ORFNames=WN51_06606 {ECO:0000313|EMBL:KOX69519.1};
OS Melipona quadrifasciata.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Melipona.
OX NCBI_TaxID=166423 {ECO:0000313|EMBL:KOX69519.1, ECO:0000313|Proteomes:UP000053105};
RN [1] {ECO:0000313|EMBL:KOX69519.1, ECO:0000313|Proteomes:UP000053105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0111107301 {ECO:0000313|EMBL:KOX69519.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KOX69519.1};
RA Pan H., Kapheim K.;
RT "The genome of Melipona quadrifasciata.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KQ435888; KOX69519.1; -; Genomic_DNA.
DR STRING; 166423.A0A0M8ZU25; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000053105; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF373; PROTEIN SON OF SEVENLESS; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000053105}.
FT DOMAIN 207..394
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 555..706
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 742..981
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1022..1046
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1074..1108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1122..1215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1244..1286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1132..1155
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1184..1208
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1259..1273
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KOX69519.1"
SQ SEQUENCE 1286 AA; 145323 MW; CD2C620505BA8480 CRC64;
VEMFSSPASV VREPSGYDFQ KEENATKWKG VFVNSLRKVL EQVHPSLEAR QDALDYVESL
ILRLLGMLCG HPPPHTPQDV EERVRRTFPT PIDRWALRDA RDALEKGKKK SPLVLPVDKI
HQLLQKEVLQ QKIDLQVSLF VVGVLEYISA DILKLAGNYV KNIRHVEISC EDIRVAMCAD
MVLMDLFYQD DYVESPQSGL GAVVSQTYEE SVRDLIHDER YYLRDLHMII KVFREEIAKL
AQDRTEIETL FSNIMDIYEV TVTLLGSLED IMEITEEKQT PTVGSCFEEL AEAAEFDVYI
KYAKDINSLA SREVLTNLLS KPEANNALRA AGHGFKEAVK YYLPKLLLQP IWHCFLYFHY
IKVLQKRTPN IEDGETLEQV QGLLSPLQME LLQSMASLPK KDTGLRMQSR ARRQAALEKT
SELQKTVDGW DQRDVGQCCN EFIREDMLWK VSNGKRLTER RALLFDGLLV LCKPSGGKRV
SVTAAAVGVV GHPPHQGELR LKERFFIRKV DIIDREDTED EEKKHPLKLP PPHLYKFAEQ
DSSENIVLEA RENGGVPLIK GATLVKLVER LTYHIYADPA FVRTFLTKST DAGILYMSFC
SPQELLTLLI ERFDIPDPSL VYGEEEKSSG CKTTAREDWK RYRKEFCQPV QFRVLNVLRH
WVDHHFYDFE RDRNLLEGLQ SFLDTVSGKS MRKWVDSVIK IIQRKCEPSE QRPITFSFER
SPPPIEWHLK VPEEEWGILT LHPIELARQL TLLEFELYRT VKPSELVGSV WTKKDKEKTS
PNLLKMIKHT TNFTRWVEKT IVEAENLEER VAIVSRTIEI MMVLQDLNNF NGVLAIVSAM
GSASVFRLKF TFQQIPARLE KALEEARELN NGHFRKYQEK LRSINPPCVP FFGMYLTNIL
HIEEGNPDYL RGSPELINFS KRRKVAEITG EIQQYQNQPY CLSVEPRIRH FIENLSPFDP
NMKEVDISNY LYNKSLEIEP RGCRQPPRVP RKWPDLNLKS PGIKARSLSG KLPAPLQAVA
SSVRLHDPPS EAPPPELPET PPHTSHVTIS HVVDHSIFAP VLLGGTVQSG SPGPFNMSGL
SISSPGSSPQ LGSPGHLSVP HHQPQNSLFG FNSATIGVMG ALTGIPSSGG SPGAVMPPPP
SPGHVPPSQP PPPLPPRSHR KRESSINESL QQARQALNAP TLPPRDGTSP PPLPPRRDLP
PVTLPPRLPT TLNPSCSTLL ARRNSTLENT CSSNAVHTRR HMSFNGPSLA KVPPMQPNGS
IIPRLPPKPL RPPTTMFNFN APPGSS
//
