ID A0A0M9A2L6_9HYME Unreviewed; 2088 AA.
AC A0A0M9A2L6;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Protein still life, isoforms C/SIF type 2 {ECO:0000313|EMBL:KOX74663.1};
GN ORFNames=WN51_13097 {ECO:0000313|EMBL:KOX74663.1};
OS Melipona quadrifasciata.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Melipona.
OX NCBI_TaxID=166423 {ECO:0000313|EMBL:KOX74663.1, ECO:0000313|Proteomes:UP000053105};
RN [1] {ECO:0000313|EMBL:KOX74663.1, ECO:0000313|Proteomes:UP000053105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0111107301 {ECO:0000313|EMBL:KOX74663.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KOX74663.1};
RA Pan H., Kapheim K.;
RT "The genome of Melipona quadrifasciata.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KQ435783; KOX74663.1; -; Genomic_DNA.
DR STRING; 166423.A0A0M9A2L6; -.
DR OrthoDB; 25601at2759; -.
DR Proteomes; UP000053105; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01230; PH1_Tiam1_2; 1.
DR CDD; cd01255; PH2_Tiam1_2; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 6.10.140.680; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR003116; RBD_dom.
DR InterPro; IPR043537; Tiam1/Tiam2/Sif.
DR InterPro; IPR040655; TIAM1_CC-Ex.
DR InterPro; IPR000697; WH1/EVH1_dom.
DR PANTHER; PTHR46001:SF2; PROTEIN STILL LIFE, ISOFORM SIF TYPE 1; 1.
DR PANTHER; PTHR46001; TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF02196; RBD; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF18385; Tiam_CC_Ex; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00455; RBD; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00461; WH1; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50898; RBD; 1.
DR PROSITE; PS50229; WH1; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000053105}.
FT DOMAIN 46..164
FT /note="WH1"
FT /evidence="ECO:0000259|PROSITE:PS50229"
FT DOMAIN 980..1093
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1266..1333
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT DOMAIN 1349..1425
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1532..1726
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 172..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 261..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 644..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 730..786
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1231..1252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1499..1526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1916..2069
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 644..668
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 669..685
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 730..751
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 764..780
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1235..1249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1500..1526
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1922..1965
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1966..1985
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1986..2002
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2003..2021
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2047..2069
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2088 AA; 236556 MW; 5E86613C29FB6AFF CRC64;
MGNKLSCSCA PLIRKAYRYE DSPWQAGARG GIGGSGGRRG DTGHLLRCGS LRERKRLWAE
VFHVSASGAG TVKWQQVSED LVPVNITCIQ DSPECIFHIT AYNSQVDKIL DVRLVQPGTR
IGQASECFVY WKDTMTNDTW GLNFTSPIDA KQFRECCSPS FKISRKASSS YSLKLEPPNK
QKIKTRRKPL STPASPSRSR EPQCTCMTPE QLARFRSQEA RYRSFCGTST LPRTMARSTE
VEMTPARDKI TAATSSASLY DNVNNTNITP GKTSKAGESK QKEKQNETCQ TTPKMANVGI
ETVTVGSQID SPEEKVAGIS PKKGQKQNQD SSIQQNNTEM LKSEGTQAGG TLQNKSLRKD
QLHQTKSADY TDLEMQNGNI FNIVNNNHSG KKSKSKSTDD MRIENAQNGG INLDSNTLKR
MLKPISSIDS PVTSPEMTRK RHSHHNYHYH PSNNNQKYIM QETENENCAH LYRAPYNNKF
QATRSVHDMG RQYTAEYNHH IVSNSCMKHL FVVGGRARTY LDSERNRCTG DMSPPSDNVI
FDNQCYATTP SSSNGNSDME QPTHCSLRRC NGGQPYQQQN MQSVSTPGSP TSRLLLEYEM
HLRNTLAKGM DAESYSLRTF EALLTQSMED LEFAKNIPLN IQRTPHVSRR RSGSNKSSTL
PLSYRYSNER QNSKDRDGYY SDRNEMIREK RDREIDRDRG YLSDYNSRCT SCVGESARAQ
WFRHSDGWQS GSSTLGSGAS SSMNPSYTGH KRDSPWDSLP SLRHEGSLND SGYKSNRTDS
LEQRGTFDRQ DSIRSDYMSD RDGRYGIVQQ ASLESTDSRI CYLTSSENVR EKVNFGLGDG
YYYKLLRIIN SALNTWAQHY IDGFSIARKE IMFKINGTAK KNMKLLKEGC YCHYHPHMTA
DACNADFLKK VVSFWAGEGL RGIREKLRGM TNYAKKMSDD DKMSLTTAVS DDDDGESVIN
SPYRGKQTGT AAASFNCTGA VRKAGFLSVK KWLLRKKHQI ELARKRGWKG YWVCLKGTTL
LFYPCDSQES RAMEAAPKHL IIVDGAIMQP IPEHPKRDYI FCLSTAFGDA YLFQAPCQVE
LENWVNSIHS ACAAAFARHR GKTGTLHLLQ EEIFRLEKAI ESDHKLKHMA DLQQSVVSDV
ETRQQINNQI IQWEENLERL HCEQFRLRCY MASLQSGELP NPKSLLTHVS RATKQTLNKL
GVFTVSSFHA FICARSPSLL NNLLAGRGAT KRRPPLLSRS NSGSSRRSLQ ISSRDDEKTV
KVYVPENQLY LKIYLYLVSV FVRDAMTVEE FLASACNRKN LNPMEHFVRV KKRRDMEDHN
YFVPHRTDMI ETYLHTHEIV EVCAKILYQV ELQRNTLEQM WGFSVEAELI ENSDRQDELC
CYVSRVEDKS VAMQNGIIKG DEIMVINGAI VSDLDMMYLE SVLQEEVGLC MMMRSSRTEP
PDLTGIMRVT DDIIESLVCP PPPSEPPVIS EEMISGLIVP APGWKNLLKT AEQVTGICRS
PGETRKSSPT GSVVSSHSQA MTPSRQLTDA EKLKKVILEL IETERTYVKN LNNLLENYLE
PLKRETFLSN AEINALFGNI QEIVTFQRQF LQNLDHAIEM ETDFNNFDHP SQFKGVLFSI
GSAFLYYVNH FKLYSSFCAS HSKAQKVLHP NEGNQALQEF LQARNPRQQH SSTLESYLIK
PIQRILKYPL LLQQLRNLTD ERSEEHQHLI EALKGMEKVA EHINEMQRIH EEYGAIFDHL
FRQHQKSCKQ PIDLSPGDLL YYGGVEWLNI SDFLGKIKKG LELHAMCFVF KSAVVFLCKE
RLRQKKKLMG VSTKVNSSEV EIIRYQVLIP VTEVQVRASS AKDMESHFLW ELIHLRSQLQ
RRSEKVYVLS NSTTEFRNAF LRTIRQIIRE SVRNMNIPST KQNLSQSSIT ISPRMSTGHV
EKFEKQSTNQ VQNGSNSSTT TIGTLSKKTA KPQLLPTSHN IKRKYSQSKQ ITEHESSEDK
DTEEPAGVIN QQQTFRSRSK TISDTSGEIK VEMDSGTKSE GEEDSQAFLG SPIWKPRELP
SLGESTTLPR KGKSASEFGD INSSHSASRK SLIEINNCAQ QSNCNNHI
//
