ID A0A0M9A896_9HYME Unreviewed; 3961 AA.
AC A0A0M9A896;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Protein toll {ECO:0000313|EMBL:KOX77953.1};
GN ORFNames=WN51_05841 {ECO:0000313|EMBL:KOX77953.1};
OS Melipona quadrifasciata.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Melipona.
OX NCBI_TaxID=166423 {ECO:0000313|EMBL:KOX77953.1, ECO:0000313|Proteomes:UP000053105};
RN [1] {ECO:0000313|EMBL:KOX77953.1, ECO:0000313|Proteomes:UP000053105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0111107301 {ECO:0000313|EMBL:KOX77953.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KOX77953.1};
RA Pan H., Kapheim K.;
RT "The genome of Melipona quadrifasciata.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; KQ435727; KOX77953.1; -; Genomic_DNA.
DR STRING; 166423.A0A0M9A896; -.
DR OrthoDB; 927694at2759; -.
DR Proteomes; UP000053105; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 5.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24369; ANTIGEN BSP, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR24369:SF203; TOLL-6; 1.
DR Pfam; PF13855; LRR_8; 5.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01217; PRICHEXTENSN.
DR SMART; SM00365; LRR_SD22; 6.
DR SMART; SM00369; LRR_TYP; 16.
DR SMART; SM00082; LRRCT; 2.
DR SMART; SM00013; LRRNT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 3.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 4.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000053105};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..3961
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005831074"
FT DOMAIN 1931..2063
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 99..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 733..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2281..2302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3579..3604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3737..3781
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3907..3961
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..123
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..389
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..490
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..514
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 733..748
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3746..3781
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3911..3937
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3961 AA; 441719 MW; 3FA4B626DCF6B533 CRC64;
MRGYVLLLVC LSLIASSWGR NLILGRRLPN DVVIENRFIF KPPVPHVGHR VIINATAPPG
YEISFIKAIN LNPRVINISL LKGYLGHQSV VLLAVTKPAS TSSEPAPTST EPAPTPSEPA
STPSEPASTP TEPASTPSEP ASPPAEPAPT PSEPASTPSE PASPPAEPAP TPSEPASTPS
EPASPPAEPA PTPSEPASTP SEPASPPAEP APTPSEPAST PSEPASPPAE PAPTPSEPAS
TPSEPASPPA EPAPTPSEPA STPSEPASPP AEPAPTPSEP ASTPSEPASP PAEPAPTPSE
PASTPSEPAS PPAEPAPTPS EPASTPSEPA SPPAEPAPTP SEPASTPSEP ASPPAEPAPT
PSEPAPTSTE PAPTSTEPAP TPSEPASTPS EPASTPTEPA STPTEPAPTP SEPASTPSEP
APTSTEPAPT PSEPAPTSTE PAPTPSEPAP TSTEPAPTPS EPAPTPSEPV STPSEPAPTP
TEPAPTPSEP ASTPSELTST PSTVATTSEE DNWPPVWTET DKIEQPSTPI VPSWVRLSLW
EGFMFIRGVF SALDSNKIQL NFAQNHKLED RICYLKFSIS VIADFGGKER RSALGVYNGV
PESQLALLKT FSNIAVLCTF TQEEFIHMVN DVLWSYERYR QDSIIANNCG TFVATRAVLL
SCLLVNSPTS IIPENVNVAP AHRIPLPKLL LVIRNTEKRM IRFNKVARAI FEFPAVLSHG
SSRSPFHRFP VNSVSTSTPI NPRSPKKREQ TNAQIRRNNK FEGSFSFHEI SKKVPAFTER
EKQSEIFRHL IKERHIVLHF TGNILKLIKR LIKIRKMRQN RFKWFRKLIT PTVAKRLKKR
TKSQITELVS QPILNNKRNV QEDVIAKGRY KTVKSLSQSA FERKIIVSND ALIPTETVSR
KPTGSANEGA LHGNVEQWSV YVTISIIRRK LGAIRPRGAH IEDKCRAGGI SQDLQARSSE
ELFREWSLAR VPFSIGKEIR MNESQLVGLE SSRWVAKRSV ECHCTMFEIR GKLELATYFQ
FPDSSSVFPS DTGQSPELKK PTLNLCRGGN ADDCSDPTIP FYPGKAKWGL DGGGGGDGDG
DGGGGGGGGC WNMGLSMFKD SPPSGHVLHA SERSFFITTC REKHGIWVRG LTRRGISERH
RRKKDLIQPL VDFQRLRVLN LSSNAISIVE DEALHGLRSL ETFDLSGNRI VALPTDMFRD
AAKSLKELRL QNNSISVLSP GLVADMNQLV ALDLSRNALT SSWLNAATFS GLIRLVLLNL
SHNRITRLDP ALFKDLYTLQ ILNLQYNEIE TIPADTFAPM SNLHTLDLAY NRLTYLDAYS
LNGLFALSLL SLDSNQLEGI HPDAFRNCSS MQDLNLSGNS LDSIPVALKD MRMLRTLDLG
ENQIRSLNRP GFRGMSSLYG LRMIGNEITN VTTEDFAELP ALQILNLARN RIEVVEDGVF
SANPALQAIR LDSNLLQDMN GMFASAPGLL WLNMSDNMIM QFDYGYLPEK LQWMDLHKNL
IMDLGFAPQG MRLQTLDVSF NRLTRIHSRS IPDSIELLFV NDNLIQTVEP QTFFDKINLT
RVDLYANQIV KMNLSALQLT QMSAYRQLPE FYIGGNPFIC DCTTEWLQRI NSLSLRQHPR
VMDLESVYCR LPYDRHKSFI PLLEAKPSQF LCTYKAHCFA LCHCCDFDAC DCEMTCPTNC
TCYHDQSWSA NVVDCSNSGY KTLPGRLPMD ATEVYLDGNN FGELNSHSFI GRKNLQILYA
NDSNIIAVRN HTFSGLKRLL VLHLENNKIS VLNGVELMPL ENLKELYLQN NLLTYIDNGT
FLPLRQLEVL RLENNRLGTF AVWQLGQNPY LVDIGLSSNP WSCECSYLDR MREWMSRNRA
KISDWRSVTC SLGMPITLPA NGSVINCAAL TGTTSVIETR PLEAYLPLLL ATAVLIFAMV
ALTAAFEDQE KPFDAYISYS AVDEAFVSTI LVPGLETSYR LCLHYRDLSA GSNVADAVAE
AADSSRRTIL VLSKNFLHGE WARFEFKAAL RDALKGKGRS VILLLVGGVC PRDLDADLKK
RISSHTVLVW GDKLFWQKLR FAMPDVSPVP VLERPLPLPP PPPPPAQHQW TFDFGHDVRV
GYTIKRNDPQ KDILSMNTTC DGQKIFFASS QFEKIQNPSR NFPSAFHDKF KQRWSCIAKF
GASRNLERGE SCIVKNNKIR QDVVGSNLFY VLVIWDLDDR RPSGADIALL SRWGDRVEVF
FPGYQFELID NLSHSVFDIL RIGIVTQLED FVGQTGRRTD TRAGTLRGTK MADEIKRRAR
RRAEGRAKKV DGTEKQRKEG SWEWENETLR NQGNEISNVA EETGEEEYLL FSFYELYFCK
HDSQVEVSVE IVFTFERASV QTWVEPDLSQ ISEGLESVLA RDWIQDVRNT GDGLSPGIIH
SGGNPDNRAS SGATLMQRKL AIALCQPSQK RQSQRDEYSL GGKGTLGIDR KPGGNERIDA
ASKESARSFR AGAHTPLAHF HHWTIITGYI EGCFIDRKIV SAFLIKLFLI ANFLDFQVFE
LSYSEVRLER IVTHRLDNIL RKCFNFIWKY ETGKYMVVGI ISALICLHDR CAIRTIRDVL
HTRTERKKLS NWFVEQIQLV AEKFENTCYE IPIYQTTSGK KNLTFNENLQ CGTNPKIGNN
HVGEECFENS PHFNFFYSQE KRTLLITLAN GILAILAILT KYVCITLLRL YDIFNEKSTA
FRGNYPTPRC TSVENAEVDE SVPPRLQMAL VTPRYVETGG GGRWLDEIYI RSISEKYGTK
RDTPYKRTVE SKKYLKTFER QCRFHLGHVE FRVDRGELWI CRRLCCIVSS LRWIQVKGRS
NLEGEAWYVT WNQPPMPTYG KKHRLGLWWG SCCCLDLWVN DLEHSDVHSI EIQVSGHVVR
YKEPGVYSFS NYQINALDKI NIGTCYKLEL THLRINVFGL IGGNPENQAY LGATLMQRKL
AIANGCMDND GKTAISQSIL NGIPNFREFA SVVKAKALAK TLISHRPRRN LSTANPLVQH
VTIPTNQTWR FATQTHKIQK KKKKKKENVL VNFPFCNPGT KEVEVNGHWI KERSKQVSEK
VPLGALLEIT QSITILFNNN GSKKTRLLIS RNIRIRKLNF PPGGAKGIEE KNAERKYYGI
VDASVQEKRQ RIKTDLLREE KSSASQRVRR LESWRPVDYP GRNSLETTDY LTWKMNSLEV
VLNISNTFVA FEDTKKSPEG RAKGRKKQKF YPSARQFKVV SRYDLLSNRC HRSNGPTNHY
HLLSSQQYLG VWGGIVTKTS TLLTTRNTYN TNSKKYCAYL DAQKCPLAEN NFPKPITKPL
NPPVKRLIQE ERTDVNSKFA NKYQRDKLSN FKISNLIVHA DCKIQNLRRE HSVGKPVWRK
YYVPVGPGKS SGLTVAHSKK KEIFFSSTCE KSTCEKKKSI SRYLERMDGT DQRQERDPNY
ATRSFNYFER CRPPGAAQPQ RTNLNVRNSI LRLPVLDPEK GVYPNPKSFA VETAAGRKNR
EPVETVVEKW KKLPRSPGAN GARELQQPGR GNFVEFHGNK GQSVKAIARE DDGGVLNISL
NILSLPKVIE SERAVKDVEG DRSALAKLNG NQLHILIGHP ARKPRAKAES SPRPNRQPAS
HDVEEQTWRL HHRLSHTINS GSQDARAIMS SERYISVAEN AKLIKIYSVQ IEVSKLLARC
SVPSLAVLYG VGCDGGGERC NGETVLAALS WWTGRNGQLI VGTVEENSES VLSAKKSWAA
KLGRGILEKR KRTWRPKRWG KGEGKLARKR RYGKEKEEKR EKEEEKKKKM KKKEKRAEER
RAFNDVHPRV TTATEVGSDA SKWRRGPLVS LLRGHLGAIS PGKKGRPTAA PAPAPAVPAA
EAVVVKLFKV VLISILVPYH FHKKSLHIAV QPVQPVKRCV HFTIKLLTGT VSKLRYVASF
DTIGDTPMEV SSSDDDSRST EEKEESDRRR DNEMGWKVQN NEKQLRVTAE GPTDPEVTWV
M
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