ID A0A0M9A8F8_9HYME Unreviewed; 1222 AA.
AC A0A0M9A8F8;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
GN ORFNames=WN51_05887 {ECO:0000313|EMBL:KOX77999.1};
OS Melipona quadrifasciata.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Melipona.
OX NCBI_TaxID=166423 {ECO:0000313|EMBL:KOX77999.1, ECO:0000313|Proteomes:UP000053105};
RN [1] {ECO:0000313|EMBL:KOX77999.1, ECO:0000313|Proteomes:UP000053105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0111107301 {ECO:0000313|EMBL:KOX77999.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KOX77999.1};
RA Pan H., Kapheim K.;
RT "The genome of Melipona quadrifasciata.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367033};
CC Single-pass type I membrane protein {ECO:0000256|RuleBase:RU367033}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|RuleBase:RU367033}.
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DR EMBL; KQ435727; KOX77999.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M9A8F8; -.
DR STRING; 166423.A0A0M9A8F8; -.
DR OrthoDB; 2971005at2759; -.
DR Proteomes; UP000053105; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR CDD; cd08781; Death_UNC5-like; 1.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582:SF47; NETRIN RECEPTOR UNC-5; 1.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF00090; TSP_1; 2.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 2.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU367033}; Membrane {ECO:0000256|RuleBase:RU367033};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW Reference proteome {ECO:0000313|Proteomes:UP000053105};
KW Transmembrane {ECO:0000256|RuleBase:RU367033};
KW Transmembrane helix {ECO:0000256|RuleBase:RU367033}.
FT TRANSMEM 433..454
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT DOMAIN 180..297
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 599..710
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 971..1037
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 37..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 520..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 918..944
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..63
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..550
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 923..944
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1222 AA; 135620 MW; DAFFCCE9B0B62240 CRC64;
MIRTPSFHQQ REIFIPSTST IAYEKKMRVK YLKSRESRPL LPDTKEEEDD AEEDDEENYP
VDDYDYGDYD TATITSDIDL IVGGSLPIFL AEPVDTFVVK GKPATLHCRA AHALQVYFRC
NGDRAERSQH QDFVDPRTGT RVVEVELNVT RNEVEEYFGR ERFKCECVAW SGPGQIRGQP
ATVEVAYLKK HFLSPPYSLS VEAGRNAELR CTPPLGVPQP KVYWLKNGSP LEAVASSTPA
SSVADGIPND VTAANSFVQT GDGHLILGRA ELRHQANYSC VAENIAARRV SEPAVLTVYV
NGGWSSWSGW SDCSARCGRG VQKRTRTCTN PAPMNGGQAC PGPATQRVEC NPSCPAVDGR
WSSWSSWSAC GLDCSRVRRR SCNDPPASNG GRPCQGKDVI VESCSMDRCN ALGQDGPRVF
KEATRAIDQR NILALWITLS LAAIILALTT IFFVRLMRRK ERMEALYGVA RLDFRRPGEL
AKSVVSKNDR SVLSVDRRLE QVIDESNACR MPRSCSEHHY DVPQLSLPST TRPSPSSSVA
RSSCRNSQRG RGLSDNEEGR SSRSTCQANQ ESTNEDDDEH EDEERLGEED RSHDDSSGFI
VRAMVDEQGA LLVVSEVGVS MSVPEGAISR GRRHGLHLAV LGDDTLRPGL PPGLTLLSAV
VACGPSGIDL VKPVILQFEH CAELRTGNWE LSLCSSLASG STWRKILTLG GEPINLPGQP
FAQLDHSGVF LVTENPSVYA VAGENSVVAP GLAVKRICIV AFLSRERDHI RCHLMEDTKA
AFKLIVEQSF NLVPGFYAFL ERLISVWLKS TLKISLEKFI QERRLGGSRI DHGTLGFRAG
GSPLRIDLED RESGFVERQE VPHRRIWSST RTSVRRSFRI EKTVGDVRLS FELRACQCGF
EEHALFLRID LDLMKRNTSS GKKTTKSESS IVLRGKNSNR STESVVPRPF RFSKTLRKQL
CQCLDPPSVR GNDWRMLAQR LQVDRYVDYF ATKASPTEHI LDLWEAKHQE ATALADLLNH
LRLMGRVDAA NVLESRLEKD LRDIYVPNFS RSLEPTEAPR RETQTRRSAA CKESGRQRFC
RSSMHVVQKL HSLIAVQPNA LGANLNDRLL WGQCVEGAAI NTAINRRHKS LALLPAGIDI
VVAGAIGSSL NLERATTDER RDGEPRPRAR NKDANWELGF IEVMKNGIQE GSQFLLLSSV
ESDENSADRI GGALVAEHIP LL
//
