ID A0A0M9WHI2_9EURO Unreviewed; 1354 AA.
AC A0A0M9WHI2;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=RNA-dependent RNA polymerase {ECO:0000256|RuleBase:RU363098};
DE EC=2.7.7.48 {ECO:0000256|RuleBase:RU363098};
GN ORFNames=ACN38_g4048 {ECO:0000313|EMBL:KOS45065.1};
OS Penicillium nordicum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=229535 {ECO:0000313|EMBL:KOS45065.1, ECO:0000313|Proteomes:UP000037696};
RN [1] {ECO:0000313|EMBL:KOS45065.1, ECO:0000313|Proteomes:UP000037696}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DAOMC 185683 {ECO:0000313|EMBL:KOS45065.1,
RC ECO:0000313|Proteomes:UP000037696};
RA Nguyen H.D., Seifert K.A.;
RT "Genome sequencing of Penicillium nordicum.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.48; Evidence={ECO:0000256|ARBA:ARBA00024517,
CC ECO:0000256|RuleBase:RU363098};
CC -!- SIMILARITY: Belongs to the RdRP family. {ECO:0000256|ARBA:ARBA00005762,
CC ECO:0000256|RuleBase:RU363098}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOS45065.1}.
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DR EMBL; LHQQ01000050; KOS45065.1; -; Genomic_DNA.
DR STRING; 229535.A0A0M9WHI2; -.
DR OrthoDB; 5477883at2759; -.
DR Proteomes; UP000037696; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProt.
DR CDD; cd00590; RRM_SF; 1.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR007855; RNA-dep_RNA_pol_euk-typ.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR23079; RNA-DEPENDENT RNA POLYMERASE; 1.
DR PANTHER; PTHR23079:SF55; RNA-DIRECTED RNA POLYMERASE; 1.
DR Pfam; PF05183; RdRP; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
PE 3: Inferred from homology;
KW Nucleotidyltransferase {ECO:0000256|RuleBase:RU363098};
KW Reference proteome {ECO:0000313|Proteomes:UP000037696};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU363098};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW ECO:0000256|RuleBase:RU363098};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU363098}.
FT DOMAIN 51..93
FT /note="RRM"
FT /evidence="ECO:0000259|Pfam:PF00076"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1253..1320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1354 AA; 152928 MW; 18C807225F461970 CRC64;
MEGPEIHNTK HSQPNHPGLG SPKPPGPRHT SPVRDWVTWR AWKTCAVDLF NIPREMNTHD
IYDAFSKYGH LISIDVWEDA SGRPDSKGRI RFKPPPNEEF WKTGSFGVKL RSGRVTVLSL
SVCCGDSNGT IPSPVRPDVQ LPNELELKTV QVDIGVLLGP STVHSMQSFA NLAFPRCVVD
TMRKCLLLYF KVGIRGSETA DVTQHDYRVK ITFLQLTQIY QQYDKVTKEH SLLVILDSAA
IWHRKAKDIQ STVTEPLSWR EEDSWYRQTS VTHNPNSLKN LPTNLKKAGH IIDSGRWNVF
RITFAPDADP NTRRVGNSSH YLMLVGDIFK DYNISIKDGS HFVEKPDRPV PVWQWIDFSE
SKSNKASALL QDLGDQNYLH LPFKVRYQLE VCLSHGYLSE FTMTREFVER LKDLGDDQAT
RLLEFVATEK KQYLDPMEIL DLKFFKGVTD SKIPSYCCFM HTARVTPTTI YYNTPTVDIS
NRVVREWSTK GAPGRFLRVR FTDERTEGRI NASLGDSNDE IYTRVKRTLA NGITIGDRRY
EFLAFGNSQF REHGAYFFSP DAGVSAATIR AWMGQFNHIR NVAKYAARLG QCFSTTRAFT
GSSVQTTQCD DIVRNGFTFS DGVGKISKFL AQMVTSQHDI KTLTGEPPSA FQFRLGGAKG
MLVVSSDPFP QEVHIRPSQQ KFETNQVGLE IIRWSQYSLA TLNRQLILVL SALGIPDKVF
HSKLNTMLGS FHRAMCNDSK AINLLQKYVD PNQTTLTLAQ MVSDGFRKNE EPFVNTMLEL
WKSWHLKHLK EKAKVAIDQG ANLLGVMDET GVLKGYFRNA LPHKRASYAE RLAALPEIFV
QICRLDGAGG YEIIEGLCIL ARNPSLHPGD IRVVRAVNRP ELHGLRDVVV LPQSGDQDIA
SMCSGGDLDG DDYLIIWDPD LIPASWFVEC MDYKGSNAPD LDHDVTVDEI TSFFVTYMKN
DCLPRIAHAH LAWADRLPKG VWEERCIRLA QLHSDAVDYN KSGAHARMAR SLDPKFWPHF
MEKRFKRPSS IYRSTKILGQ LYDAVVTPDF IPKLEKPFDS RVLESPLAPT SETYMEYARD
LKAEFDMKMR QIMAQYEINT EFEVWSTFVL RHGFVIRDYK MQEDLGRIVG TLRRGFRHQC
YDKVSRHGGN IAALVIAMYR VTQEQVAAAL EARRKEALQR EDLSIVEVST TELPLISFPW
IFPDVLGDVA TGRARQAPLE GQEGAASTKP IGDGMVFTHS QILQIVEDMD EDMKPKGEEN
KKPKAEAGSG SAPPAQELIA RRRIDKTKSK PTPENMNGGV CFDDEDDENE GGVSLGAAKA
EEKIEKESVV EDIVEMEGDI QPSALDALIN MINN
//
