ID A0A0M9XAR7_9ACTN Unreviewed; 385 AA.
AC A0A0M9XAR7;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Cystathionine gamma-synthase {ECO:0000313|EMBL:KOT44133.1};
GN ORFNames=ADK41_04455 {ECO:0000313|EMBL:KOT44133.1};
OS Streptomyces caelestis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=36816 {ECO:0000313|EMBL:KOT44133.1, ECO:0000313|Proteomes:UP000037773};
RN [1] {ECO:0000313|EMBL:KOT44133.1, ECO:0000313|Proteomes:UP000037773}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL B-24567 {ECO:0000313|EMBL:KOT44133.1,
RC ECO:0000313|Proteomes:UP000037773};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOT44133.1}.
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DR EMBL; LGCN01000040; KOT44133.1; -; Genomic_DNA.
DR RefSeq; WP_030830337.1; NZ_LGCN01000040.1.
DR AlphaFoldDB; A0A0M9XAR7; -.
DR PATRIC; fig|36816.3.peg.951; -.
DR OrthoDB; 9780685at2; -.
DR Proteomes; UP000037773; Unassembled WGS sequence.
DR GO; GO:0016846; F:carbon-sulfur lyase activity; IEA:UniProt.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:UniProt.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR11808:SF92; CYSTATHIONINE GAMMA-SYNTHASE; 1.
DR PANTHER; PTHR11808; TRANS-SULFURATION ENZYME FAMILY MEMBER; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE 3: Inferred from homology;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR001434-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000037773}.
FT MOD_RES 204
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ SEQUENCE 385 AA; 40699 MW; DD33803ABD382437 CRC64;
MSDRHISQHF ETLAIHAGNT ADPLTGAVVP PIYQVSTYKQ DGVGGLRGGY EYSRSANPTR
TALEENLAAL EGGRRGLAFA SGLAAEDCLL RTLLGPGDHV VIPNDAYGGT FRLFAKVVAR
WGVAWSVADT SDPAAVRAAI TPNTKVVWVE TPSNPLLGIT DIAAVAQVTR DAGARLVVDN
TFATPYLQQP LALGADVVVH SLTKYMGGHS DVVGGALITG DAELGEELAY HQNAMGAVAG
PFDSWLVLRG TKTLSVRMDR HSENATRIAD MLTRHPRVTS VLYPGLPDHP GHEVAAKQMR
AFGGMVSFRV EGGEEAAVEV CDRAEVFTLG ESLGGVESLI EHPGRMTHAS AAGSALEVPA
DLVRLSVGIE NVDDLLEDLQ QALGR
//
