ID A0A0M9YHQ9_9ACTN Unreviewed; 1204 AA.
AC A0A0M9YHQ9;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Regulator {ECO:0000313|EMBL:KOU47708.1};
GN ORFNames=ADK54_12425 {ECO:0000313|EMBL:KOU47708.1};
OS Streptomyces sp. WM6378.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1415557 {ECO:0000313|EMBL:KOU47708.1, ECO:0000313|Proteomes:UP000037774};
RN [1] {ECO:0000313|Proteomes:UP000037774}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM6378 {ECO:0000313|Proteomes:UP000037774};
RA Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the AfsR/DnrI/RedD regulatory family.
CC {ECO:0000256|ARBA:ARBA00005820}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOU47708.1}.
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DR EMBL; LGDD01000120; KOU47708.1; -; Genomic_DNA.
DR RefSeq; WP_053725644.1; NZ_LGDD01000120.1.
DR AlphaFoldDB; A0A0M9YHQ9; -.
DR PATRIC; fig|1415557.3.peg.2778; -.
DR OrthoDB; 499349at2; -.
DR Proteomes; UP000037774; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd15831; BTAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR005158; BTAD.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR47691:SF3; HTH-TYPE TRANSCRIPTIONAL REGULATOR RV0890C-RELATED; 1.
DR PANTHER; PTHR47691; REGULATOR-RELATED; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF03704; BTAD; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM01043; BTAD; 1.
DR SMART; SM00028; TPR; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS51755; OMPR_PHOB; 1.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU01091};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 1..93
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000259|PROSITE:PS51755"
FT REPEAT 955..988
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DNA_BIND 1..93
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01091"
FT REGION 246..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 633..670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..292
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..651
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1204 AA; 129529 MW; 258C1CAEF68A1C38 CRC64;
MLRYRVLGPT QALRPDGSEA RLGGARLRAL LAALAAGAGR AVPQSVLISQ VWGEGDAPPA
DEVAAVQALV GRLRRALGPD AVVSAPGGYR LAAHADEIDL FRFERLVAEG ATALAAGDAE
CAAGLLDDAL ALWQGPALAD LPARDGDPLV VRAERHQADA RRNRLAAEVE LGRAESALGE
LTALAAAAPL DEPLQALRIR ALRAAGRSAE ALAAYESVRG ALSERLGTNP GPELLALHAE
LLNPERHGES TRTGHRHTGS SYMASSHMAS QDMAPDHTGS RHTSSPHVGS SHTGSPHMAP
RDMASSYMGS QHMAAPHAGS PHMASPDAAS SPVRPPGNLR ARLTSFVGRE TDVRALHDDL
RQERLITLTG PGGAGKTRLA VEAADAAAAE WGDGVWLVEL APVRDAVSLA EAVLTALGAR
ETRLVGPAET APRDPLAQLL AHCGRLRMLI VLDNCEQVVA AAAELVEELL TACPDVTVLA
TSREPLGVPG ERVTAIGPLP HESALMLFGQ RGAAARPEFS AEADPDAVAE ICRRLDGLPL
ALELAAARLR LFTPRQIADR LDDRFRLLNT GPRTSRTLQP RQQTLRAVVD WSWDLLDTPE
RAVLRRLAVF AGGFALSEAE AVCADPEEEA VCADSKEAGT EETDPKRPGS NKPSPKKPSP
RKPGPGVGSA DVLDLLGSLV DKSLVTAAPD GDGATMRYRL LETVAEYAAQ RLDEAGERAE
VELRHLVTYR ELVRTGEAAL RGPRQREIIE RLEAEHDNIS AALRTAVGRK REQDALCLVL
AMAWFWQLRG HQADARSWSG AVAELGQDPF TEPVRLAVPL ADRCTDSPPP WSEEQLWEAR
RGVRLMVFAA RGGGDTELNS PETVAYLRRI VRAYGSGLPQ NSRQPGSVWY FARLLTGEFT
GFDRVVDEMV ADARQHGDPW DLAFALLIRA KLLVGSDADD ALALFERVGD PWGIAESLSA
RGDSYEREGR YEEAATDFER ALQRVTEMGA HAQVSVFKGK LASARLEMAR TPAEREEAER
LLAEAVEESR QFPQESLGTA RMLLAQHFGR TGRTGAARQQ LQLMEGEFTA LTPELFRGLV
AGMYGWLDCL DGKYADAQGR IQDAVRHLES QAYLVAPNLI LSQFLSAAWA KAELGAAVDG
ARLLGAYDRN STGRDSFGFR PLPAEPETRR RAEAELRRTL DPAAYERAYA EGADLDVRQA
AALV
//
