ID A0A0M9ZQP2_9ACTN Unreviewed; 365 AA.
AC A0A0M9ZQP2;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Alcohol dehydrogenase {ECO:0000313|EMBL:KOV68935.1};
GN ORFNames=ADL00_11940 {ECO:0000313|EMBL:KOV68935.1};
OS Streptomyces sp. AS58.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1519489 {ECO:0000313|EMBL:KOV68935.1, ECO:0000313|Proteomes:UP000037758};
RN [1] {ECO:0000313|EMBL:KOV68935.1, ECO:0000313|Proteomes:UP000037758}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AS58 {ECO:0000313|EMBL:KOV68935.1,
RC ECO:0000313|Proteomes:UP000037758};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOV68935.1}.
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DR EMBL; LGDU01000094; KOV68935.1; -; Genomic_DNA.
DR RefSeq; WP_053758073.1; NZ_LGDU01000094.1.
DR AlphaFoldDB; A0A0M9ZQP2; -.
DR PATRIC; fig|1519489.3.peg.2757; -.
DR OrthoDB; 334894at2; -.
DR Proteomes; UP000037758; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08279; Zn_ADH_class_III; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR43350; NAD-DEPENDENT ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR43350:SF19; RIBULOSE-5-PHOSPHATE REDUCTASE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000037758};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 16..363
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 365 AA; 37181 MW; A87F4AC16189250D CRC64;
MAVRPTVRAA VLPAVGSPLE ITGIELPDPG PGQVRVRLAA AGVCHSDLSL SDGTMRLPVP
AVLGHEGAGT VVAVGEGVTR LAPGTDVVLN WAPSCGSCPA CARGEVWLCA DALTGAARVH
ARRAADGAEL HPGLNVAAFA QETVVPASCA LPAPPGVPLT DAALLGCAVL TGYGAVHHSA
RVRAGESVAV FGVGGVGLAA LQSARIAGAE RIVAVDVTPQ KEGLARAAGA TDFVLATENT
HREIRALTAG QGVDVAVECV GRAVTIRAAW DSTRRGGRTT VVGIGGKDQQ VTFNALEIFH
WGRTLSGCVY GNCDPERDLP VLADHVRSGR LDLAALVTER ITLDGIPAAF ENMRAGKGGR
ALVVF
//
