ID A0A0N0A2G2_9NOCA Unreviewed; 628 AA.
AC A0A0N0A2G2;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Cell division protein FtsI {ECO:0000313|EMBL:KOV85895.1};
GN ORFNames=ADL03_10075 {ECO:0000313|EMBL:KOV85895.1};
OS Nocardia sp. NRRL S-836.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=1519492 {ECO:0000313|EMBL:KOV85895.1, ECO:0000313|Proteomes:UP000037746};
RN [1] {ECO:0000313|Proteomes:UP000037746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL S-836 {ECO:0000313|Proteomes:UP000037746};
RA Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOV85895.1}.
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DR EMBL; LGDY01000089; KOV85895.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N0A2G2; -.
DR STRING; 1519492.ADL03_10075; -.
DR PATRIC; fig|1519492.3.peg.2167; -.
DR Proteomes; UP000037746; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 3.30.450.330; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000313|EMBL:KOV85895.1};
KW Cell division {ECO:0000313|EMBL:KOV85895.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000037746};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 63..239
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 291..604
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 422..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..441
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..500
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 628 AA; 68269 MW; 564E43EA4B1DA4FD CRC64;
MSVRAPAPKA RNTGNNKVRI AVGRLLLIGA LVAAGLKLVQ VQGLQADELS TQARLQRTTY
LNIPAERGAI LDRNGNQLAF SVEVRALYIL PQRARKNWDA EREKEKDKAK KQFPQTYDEH
ARDVAKFISS TLGPEVNGEK TDEETIYQQL VADISYEVLV SEAEPAKAAA IVAKYPAEIG
SEYRAKRIYP NGPVASNIIG AANWRQEEKP PTTQGILGLE NAADNVLAGR MGRRVVDTMS
GDDTLVIPNT ERELTKPQPG KSLELTIDVD TQYAVQRMVT DYTQKSGARS GSAVVLDSRT
GEIIAMANDQ TYDPADFGRA TDEQKRNRAV ADTYEPGSVN KIVTAAAAVE YGLFKPDDVL
QIPGSLKVAD RTIRDAWTHG TVPMSFTGIF AKSSNVGTLL AAQEVGQERY AEMLQKFGLG
KRTQSGVPGE ESGTVPPLNQ WSGSTFGNLP IGQGLSMNLL QMTAMYQTIA NDGLRVPPRL
VRAEISADGS RSEKQRPEGV RVVSPETAKT VRNMFRSVTQ SDPRDANQNG TGSKAALPGY
QIAGKTGTAQ QIDPACKCYS SVDYWITFAG ILPADNPRYV VGIMLDRPHG TPFSGSAAPL
FHDIASFLTQ RFQVPLSSEQ TPFVQLQL
//
