ID A0A0N0AVC0_9PSEU Unreviewed; 435 AA.
AC A0A0N0AVC0;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=L-fuconate dehydratase {ECO:0000256|ARBA:ARBA00013142};
DE EC=4.2.1.68 {ECO:0000256|ARBA:ARBA00013142};
GN ORFNames=ADK67_12010 {ECO:0000313|EMBL:KOX28255.1};
OS Saccharothrix sp. NRRL B-16348.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharothrix.
OX NCBI_TaxID=1415542 {ECO:0000313|EMBL:KOX28255.1, ECO:0000313|Proteomes:UP000037722};
RN [1] {ECO:0000313|EMBL:KOX28255.1, ECO:0000313|Proteomes:UP000037722}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL B-16348 {ECO:0000313|EMBL:KOX28255.1,
RC ECO:0000313|Proteomes:UP000037722};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O;
CC Xref=Rhea:RHEA:22772, ChEBI:CHEBI:15377, ChEBI:CHEBI:21291,
CC ChEBI:CHEBI:37448; EC=4.2.1.68;
CC Evidence={ECO:0000256|ARBA:ARBA00001737};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOX28255.1}.
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DR EMBL; LGED01000113; KOX28255.1; -; Genomic_DNA.
DR RefSeq; WP_053716582.1; NZ_LGED01000113.1.
DR AlphaFoldDB; A0A0N0AVC0; -.
DR STRING; 1415542.ADK67_12010; -.
DR PATRIC; fig|1415542.3.peg.2611; -.
DR OrthoDB; 5241672at2; -.
DR Proteomes; UP000037722; Unassembled WGS sequence.
DR GO; GO:0050023; F:L-fuconate dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0009063; P:amino acid catabolic process; IEA:InterPro.
DR GO; GO:0016052; P:carbohydrate catabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.120; Enolase-like C-terminal domain; 1.
DR Gene3D; 3.30.390.10; Enolase-like, N-terminal domain; 1.
DR InterPro; IPR036849; Enolase-like_C_sf.
DR InterPro; IPR029017; Enolase-like_N.
DR InterPro; IPR029065; Enolase_C-like.
DR InterPro; IPR034610; L-fuconate_dehydratase.
DR InterPro; IPR018110; Mandel_Rmase/mucon_lact_enz_CS.
DR InterPro; IPR013342; Mandelate_racemase_C.
DR InterPro; IPR013341; Mandelate_racemase_N_dom.
DR InterPro; IPR046945; RHMD-like.
DR PANTHER; PTHR13794; ENOLASE SUPERFAMILY, MANDELATE RACEMASE; 1.
DR PANTHER; PTHR13794:SF58; MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1; 1.
DR Pfam; PF13378; MR_MLE_C; 1.
DR Pfam; PF02746; MR_MLE_N; 1.
DR SFLD; SFLDS00001; Enolase; 1.
DR SFLD; SFLDF00111; L-fuconate_dehydratase; 1.
DR SMART; SM00922; MR_MLE; 1.
DR SUPFAM; SSF51604; Enolase C-terminal domain-like; 1.
DR SUPFAM; SSF54826; Enolase N-terminal domain-like; 1.
DR PROSITE; PS00909; MR_MLE_2; 1.
PE 4: Predicted;
FT DOMAIN 198..294
FT /note="Mandelate racemase/muconate lactonizing enzyme C-
FT terminal"
FT /evidence="ECO:0000259|SMART:SM00922"
SQ SEQUENCE 435 AA; 47458 MW; C6B8CD3CB9328CDC CRC64;
MTELITAVDA VDVRFPTSLE LDGSDAMNPE PDYSAAYVTI RTSDGAAGHG LAFTVGRGND
VEVAAVRALA PLVLGLPVDE VLGDLGAFSR RLTGDSQLRW LGPEKGAIHM AAAAIVNAVW
DLYGRREQKP VWQLLSELSP EQLVDLVDFR YLDDALTRDE ALDILRRAEP GRAERAAHLL
EHGYPAYTTT PGWLGYDDEK LVRLSEEAVA DGFTQIKLKV GADPEADVRR LRLAREAVGP
DIRIAVDANQ AWGVRQAIDW MAPLLPYDPY WIEEPTSPDD ILGHAAIRRA LTPVKVATGE
HTHNQVMFKQ LLQAGALDIL QLDASRTAGV TENVAILLLA AKFGIPVCPH AGGVGLCEMV
QHLAMFDYVA VSGTTEDRVI EYVDHLHEHF TDPVRIRRGH YLAPTAPGIS AELHPASIAA
HRFPDGPVWN RQATA
//
