ID   A0A0N0K9F5_9PROT        Unreviewed;       298 AA.
AC   A0A0N0K9F5;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=4-hydroxy-tetrahydrodipicolinate synthase {ECO:0000313|EMBL:KPF85698.1};
GN   ORFNames=IP70_10745 {ECO:0000313|EMBL:KPF85698.1};
OS   alpha proteobacterium AAP38.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria.
OX   NCBI_TaxID=1523418 {ECO:0000313|EMBL:KPF85698.1, ECO:0000313|Proteomes:UP000037884};
RN   [1] {ECO:0000313|EMBL:KPF85698.1, ECO:0000313|Proteomes:UP000037884}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AAP38 {ECO:0000313|EMBL:KPF85698.1,
RC   ECO:0000313|Proteomes:UP000037884};
RA   Zeng Y., Feng F., Liu Y., Koblizek M.;
RT   "Novel Diversity of Limnic Aerobic Anoxygenic Phototrophic Bacteria as
RT   Revealed by High-throughput Strain Identification and Genome Sequencing.";
RL   Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the DapA family.
CC       {ECO:0000256|PIRNR:PIRNR001365}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KPF85698.1}.
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DR   EMBL; LJHR01000012; KPF85698.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N0K9F5; -.
DR   STRING; 1523418.IP70_10745; -.
DR   PATRIC; fig|1523418.3.peg.241; -.
DR   OrthoDB; 9778880at2; -.
DR   Proteomes; UP000037884; Unassembled WGS sequence.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   CDD; cd00408; DHDPS-like; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002220; DapA-like.
DR   PANTHER; PTHR12128:SF74; BLL4423 PROTEIN; 1.
DR   PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR   Pfam; PF00701; DHDPS; 1.
DR   PIRSF; PIRSF001365; DHDPS; 1.
DR   PRINTS; PR00146; DHPICSNTHASE.
DR   SMART; SM01130; DHDPS; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|PIRNR:PIRNR001365}.
FT   ACT_SITE        137
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT   ACT_SITE        165
FT                   /note="Schiff-base intermediate with substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT   BINDING         207
FT                   /ligand="pyruvate"
FT                   /ligand_id="ChEBI:CHEBI:15361"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ   SEQUENCE   298 AA;  32307 MW;  1B7C43A33ED4E975 CRC64;
     MAKLTWTGVY PAATTQFAED LSVDYDATAG VQDALIRDGV DGLILLGTCG ENNSLEPDEK
     RAILDRARTA VGGRVPVVAG VSELTTKRAV AFARDAEALG VDGLMLLPAM VYVPTEEELY
     THFKTVADAT SLPIMLYNNP PAYRVSISAR VLAKLADIPN IVAVKESAPD PRRFTDLINE
     FGDRFVLMAG LDDVALEGMI LGAHGWVSGL TSAFPQESVA LIKALQKGDI AEARRIYRWF
     MPLLHLDAEH DLVQSIKLAE QIMGRGSERV RLPRLPLSGV RRAQVTAMVE KAAATRPV
//