ID A0A0N0N800_9ACTN Unreviewed; 702 AA.
AC A0A0N0N800;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=MMPL domain protein {ECO:0000313|EMBL:KPI23069.1};
GN ORFNames=OV320_1117 {ECO:0000313|EMBL:KPI23069.1};
OS Actinobacteria bacterium OV320.
OC Bacteria; Actinomycetota; Actinomycetes.
OX NCBI_TaxID=1592329 {ECO:0000313|EMBL:KPI23069.1, ECO:0000313|Proteomes:UP000037870};
RN [1] {ECO:0000313|EMBL:KPI23069.1, ECO:0000313|Proteomes:UP000037870}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OV320 {ECO:0000313|EMBL:KPI23069.1,
RC ECO:0000313|Proteomes:UP000037870};
RA Brown S.D., Utturkar S.M., Klingeman D.M., Pelletier D.;
RT "Draft genome sequences for four actinobacteria strains OK006 OK074 OV450
RT and OV320.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPI23069.1}.
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DR EMBL; LJCX01000034; KPI23069.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N0N800; -.
DR PATRIC; fig|1592329.3.peg.8937; -.
DR Proteomes; UP000037870; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000037870};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 277..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..336
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 372..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 511..529
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 536..557
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 569..589
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 610..631
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 643..662
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 217..335
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 681..702
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 702 AA; 73009 MW; 096E7564840102A4 CRC64;
MGAGDFMGAG KKARSRRSAI PWVVLALWVG VLAIASPFAA KLADVQHDRV TDYLPASADS
TRVARLQEQL PGGESTELVL VYHRDGGLTA ADRTTAREQV ARVAGDHALT GAPRGVPSAD
GATLMYPVAT NEPGTDEEKR DAFVEDVREV AHSEGGLTVE VGGTGALATD AAKVYDSLGG
PLLYTTVGVV AVLLILIYRS PVLWLVPLAV AGIADYLSMG VAYGLNQGFG TTVSGQSSGI
MTILVFGAGT DYALLLVSRY REELRRVERP YDAMRAALRG CGPAVLASSG TVAAGLLCLL
AADLNSNRGM GPLGTVGVLC ALVTMLTLLP ALLVLLGRRV FWPLVPAYGS TPKVRRSLFA
AMGTSAGRRP RTVLAAGAVL LGALALGALN LPGAVKQQDS FVDRPESVVA MGTLAKAFPE
QSAQPIEVMT PAGRTEATLA AIRDTDGVAD ARQGRTGEGW TEITVTAAAP PQSAAETATI
EALRDSLTGS YVGGPSAQQI DLVDTNARDR LVVVPLVLVS VLLILIVLLR SLVAPLMLVA
AVVAVWGAAL GLGGLVFGPV FGFEGTDPGL GLLSFVFLVA LGVDYGIFLM HRMREESMRG
ADPVAAALTA LRTTGGVIAS AGLALAATFA VLTNMGLVQL VELGFVIAVG VLLDTFLVRT
YLVTSASVAL GRKVWWPGRL SRAPETARPE QPGRPERQTE PV
//
