ID A0A0N0NQY5_9EURO Unreviewed; 698 AA.
AC A0A0N0NQY5;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=E3 ubiquitin protein ligase {ECO:0000256|RuleBase:RU365038};
DE EC=2.3.2.27 {ECO:0000256|RuleBase:RU365038};
GN ORFNames=AB675_8240 {ECO:0000313|EMBL:KPI44458.1};
OS Phialophora attinorum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Phialophora.
OX NCBI_TaxID=1664694 {ECO:0000313|EMBL:KPI44458.1, ECO:0000313|Proteomes:UP000038010};
RN [1] {ECO:0000313|EMBL:KPI44458.1, ECO:0000313|Proteomes:UP000038010}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 131958 {ECO:0000313|EMBL:KPI44458.1,
RC ECO:0000313|Proteomes:UP000038010};
RA Moreno L.F., Stielow B.J., de Hoog S., Vicente V.A., Weiss V.A.,
RA de Vries M., Cruz L.M., Souza E.M.;
RT "Draft genome of the ant-associated black yeast Phialophora attae CBS
RT 131958.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|RuleBase:RU365038};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906, ECO:0000256|RuleBase:RU365038}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU365038}.
CC -!- SIMILARITY: Belongs to the BRE1 family. {ECO:0000256|ARBA:ARBA00005555,
CC ECO:0000256|RuleBase:RU365038}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPI44458.1}.
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DR EMBL; LFJN01000003; KPI44458.1; -; Genomic_DNA.
DR RefSeq; XP_018004421.1; XM_018148671.1.
DR AlphaFoldDB; A0A0N0NQY5; -.
DR STRING; 1664694.A0A0N0NQY5; -.
DR GeneID; 28740551; -.
DR OrthoDB; 53681at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000038010; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniRule.
DR CDD; cd16499; RING-HC_Bre1-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR013956; E3_ubiquit_lig_Bre1.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR23163:SF0; E3 UBIQUITIN-PROTEIN LIGASE BRE1; 1.
DR PANTHER; PTHR23163; RING FINGER PROTEIN-RELATED; 1.
DR Pfam; PF08647; BRE1; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW ECO:0000256|RuleBase:RU365038};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|RuleBase:RU365038};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU365038}; Nucleus {ECO:0000256|RuleBase:RU365038};
KW Reference proteome {ECO:0000313|Proteomes:UP000038010};
KW Transferase {ECO:0000256|RuleBase:RU365038};
KW Ubl conjugation pathway {ECO:0000256|RuleBase:RU365038};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU365038};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 649..685
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 48..75
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 155..210
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 253..421
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 530..631
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 698 AA; 79408 MW; C94573D617AB838F CRC64;
MEDRKRSMPY DQGDGPATKK QALAPNGVGK PHPDTDMPWK DDLERFTKDA ILRQMNEYKR
EKNTLKSELD EIRKKTRHHD DHIRAIDAWF KQLLDEVKTM SPGDDDEDME LSTLPTSLLF
EDQPHLEQHI TKRTKEVRTI LGKLLSRSKN FTPDVVELQK RISELQAEEK SHLLELETLR
AEVANIELRL ETATERYVVA EKKVERAKSV TVAKLEKQLK GGMKGSDDGV KKEELKNGVG
ETGEDYTRLE TEHNKVLAAS EVLKEQVEKL QEETTKLQSE VTAANAKSAT LSDEDYSKTD
LFKQFKAQHE DVIKKLNDLD ARCTQLKDEN RMLLQERTSY QNKLDDETRA TVAEKDTQLG
QVEKDLVRIR AERDDLQAKL SMEKSKNEEK LEAVFKVREL CEAQEERIKS LESETQRLQG
TSAMDVDDAQ LEGLGPDEIR TKYQSLNQNY KMLSSELTSM SAAYQKASKH AKQNTLKAGE
QEDKVQRLVA EKAKADQKYF AAMRSKDARE QEIRTLKLQT SKSSDIALQL KEAETASKAL
IANLEKQLSD MKEAHSSKTS DCRALQNEKD SNALELSRLK KQITDLTQQL TAKDAEISGK
SAATRTAEVE VKQLQSVLDS TRKDLEKWKS RSGQSDVVDD LHSIVFCHCK KNMKDTVLKT
CGHVMCSSCV EERVASRSRK CPLCSKSFGS NDYMRVTL
//
