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Database: UniProt
Entry: A0A0N0P7Y1_LEPSE
LinkDB: A0A0N0P7Y1_LEPSE
Original site: A0A0N0P7Y1_LEPSE 
ID   A0A0N0P7Y1_LEPSE        Unreviewed;      2946 AA.
AC   A0A0N0P7Y1;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   15-FEB-2017, entry version 7.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KPI89319.1};
GN   ORFNames=ABL78_1548 {ECO:0000313|EMBL:KPI89319.1};
OS   Leptomonas seymouri.
OC   Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae;
OC   Leishmaniinae; Leptomonas.
OX   NCBI_TaxID=5684 {ECO:0000313|EMBL:KPI89319.1, ECO:0000313|Proteomes:UP000038009};
RN   [1] {ECO:0000313|EMBL:KPI89319.1, ECO:0000313|Proteomes:UP000038009}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 30220 {ECO:0000313|EMBL:KPI89319.1,
RC   ECO:0000313|Proteomes:UP000038009};
RX   PubMed=26317207;
RA   Kraeva N., Butenko A., Hlavacova J., Kostygov A., Myskova J.,
RA   Grybchuk D., Lestinova T., Votypka J., Volf P., Opperdoes F.,
RA   Flegontov P., Lukes J., Yurchenko V.;
RT   "Leptomonas seymouri: Adaptations to the Dixenous Life Cycle Analyzed
RT   by Genome Sequencing, Transcriptome Profiling and Co-infection with
RT   Leishmania donovani.";
RL   PLoS Pathog. 11:E1005127-E1005127(2015).
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KPI89319.1}.
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DR   EMBL; LJSK01000026; KPI89319.1; -; Genomic_DNA.
DR   EnsemblProtists; KPI89319; KPI89319; ABL78_1548.
DR   Proteomes; UP000038009; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   GO; GO:0006816; P:calcium ion transport; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000038009};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000038009};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2451   2484       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2578   2603       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2609   2630       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2637   2657       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2716   2738       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       73    130       MIR. {ECO:0000259|PROSITE:PS50919}.
SQ   SEQUENCE   2946 AA;  325374 MW;  6423D2D6876A2F99 CRC64;
     MASTAVAQPL RYGCLINLYK QSLDGYVVAT SSAEAPVGLQ CDSVENPLRY EKTAFLLQRG
     DPVETGASRR PGGDIVKYGQ TIRLLHYAHQ QPLSYHMERH AAGMKGNLRV LLEKRGKSLL
     KVERWRIMPR YRLRVEGDPV ADGDPVLLQA ADGELYLNVA PDVDDEAADK QFFEVSVGEG
     LQGFLMCLYD GDTSPETTLP PLRCGDCVTL LHTEEQKYVL ADPSKKLCVL RTPDSQLADD
     DAVTGEAGVG DDPAVASYVA REGEVGYLSL FVVEGADARK GGALRTRGLR DFYRFKSLSS
     GLYLQCGEVP ASSSPSYAPG VADPGATTGA DKSSSAEGAA TLAASPGSGP VLPAADAAMS
     PSRLAAAGNG VRAGADVGRP ARQSTYAVTL TPNAKAPGTL FQLHCVSSSA EEFLANGGRV
     FLSCVNSRGR KVWMVAGGPA LLDGEDSREA EMTVASLAHQ AKTYGTVLLL GKGLKSMRDG
     MEIRRLQPKA LEELYMIRGL LPPLQRYVKD MTMGIGNPFQ VRQARENLLQ LQQLCQRVTG
     PGEEEGAEDL MSARNAGGGV LNPEWQSKVF QQGVGELALQ VVKATMECPY VQPEKLLSLD
     IVYPRVAGDP AGASAAGDGA AESKGTSEEA KADGAMLPQP PSLPPVAPTA IPVTPATLGG
     KVGSLSFVAM RYSELKDLIH VCFQLVRLLL YNRPRYAETL QSYADFVMEC TRYVPSALKC
     LAAFYKDNPI YVELPMARHR LDFFLHMLDE RGREPDVVHI LQHFACCGGE GMVEAQRVIL
     DFFERDPAMT QRLLCPFRRM PVAQEVRETL LTQLSESFPQ FSERLEPEGT NNGGGGVAAA
     EAEPTTGLGI GKLSIGSPLG IMKQPKGFKS SPTTSSMAKS PASPIVAELP LRSGKELVVV
     GIPNAFFAEV EGDEESVSIT TSTQYRGKCD KLGELLQRAA DAVDTDALTY FPLEGVSVMM
     EDWPEVKDLL VPYLVAQIRL LAALAYGKNK SSSKSFIFEW IPRLVLVETL KSEVLPRQLH
     AALLELFANV MLDVEGAQNI REQIQNIRCV VTRSSDAADV SAISAFRMTM RTVPEELAIA
     KKLVVRHMRR TMMSGEENTA EEYLSVLNLT DALVNTGAFD LAEYELLMQL MVQCVDPSRD
     DQRTYLEIQS VYECKSRALR LMSTVIDVLL VREALVLVDC FRQQKKPPAY SQLTVFSLNA
     TARKNAIGGG DEAPAESSDA ATESDAAVEP HGSPGHDSGI VYAVEGRKAK PEFTPIAEMF
     RALLDLANRS RSSMIQRQVI CLFFRATNFL EELHATAMRV QLLTSKASMG LYTEINRTSI
     TLDQLTKKSF RRSNTVVLAD SALDALEKFL SKAKYGATAE KLSMMCHLGV PLQLIRMLTR
     LTVPLRESSR QLTFKAVALL QVMAQSAPIR EELRVAVTDA SPLVYQDTNY ISLLRTLFVS
     EDGDRAQMPT ALLSEVVKCL YMQHSASMAI SFFCDWLVPR GSPGHVTTHR QQQLWRAIVS
     DQQAERCIQL RHSWCSDQGR EMRERLLTSD DSYAPTGRVA THLEMCRLLF LVSNNSELVK
     PEEIRQEVFG QNSLDAMLQV LTDPLLPVYF RGSYALLLQA LVLDDEMAIP SLFAHRDFPD
     FLQLCMMDAV RYLQLLGGSS VVPEIDEEVE RREDAVLRCS PTNETEEEVD EARLGRGAYE
     DFFFGPLCAC LQRVCAVYRN GISQLSNRVR SQLGMEINGV IDVLCDVMQQ VFEPPAIDAA
     VSEQSTTRPN SLRAASVSTV PFPEAQWNSK QCNALRSCLR VAKEKGFHGT ARWRGEQFVR
     MCDCLDAYRE SSAKVSTPLV ATEGQKTLSP ATPGVVVTSD TASTNTPGLQ REQGDSHALT
     SKWTEFLAES LLRDPRMTED NRLLSAAGVL LRCGARGTIF IRLLCTVMPS LQRCFLVSTL
     TLVRQLVVLM PGNPYDDSAL LPLHVLDADI PYITITTSVP SRQSFLARWS HDMSLEVPRP
     LISVVAELIG YGKQDVRRAA LLAGCTLLMK GHRSMQECFY NHCRRSSNEQ FFFILRNHLI
     EFKDELRTYY RALASGGTPS GAAQYLTHMA NCRLELKMLQ LLCAGQYRPL QTYLVAQPDN
     NISVNVVEAL VDLLSMAPKT ANEVTLDFML QFLSTIAETL QGPCLINQDT LVAYNAADYL
     TLLVSEHDPL VNPRAVFSNT EVAIPRVPWH EAHFGKKHKK KSEAALMEEK RQRCRYLLQT
     MALSTLLALI EGRDDSAFAS KLISTVDLSV LGRSMDRSAA AYEARHGPIV RRQTRGLLRG
     DVEGCCAVLS RYLRDYIHAD YSTGREELQD ELALAVSIYT FFRACHDMHT LAVTRSRRTG
     KAAQSLSGIS REIDEFVDKK SQSIRQVLRK TWSYRQVATK LATIEVVRDG RLERVYFRIL
     SSAADNLLHY RKSRLIASAV RTSDNERIQY FFNRGSEMVI EVAWYARLRR FFLIFMLNLF
     SSEINAVGLG IVLAINVVMI AGIRTPTSPY EDGTSEGINS TLRVLGIANI CVQGVLTIQA
     FFGPAMASYK IGWQLWRLSK TNRLTKRADN DIAADRDDIL QCSADTMRPS RSAYVCHSLL
     FIFTDGLFLP QIFFLFVSIM GFVHHRIWYG LQLMQISLSS TVLANLLTAL ANNSASLVLT
     LALLLIFVVF FANISYYKFS NLFNPLGNRN NGFNCYTLSQ CWLVHVDTLR SGGGIGDVMD
     WPVYYSSNSF GYWTEFFRMC YFAVVNLIGV NLFLGVIIDS LAKYRQEQQF VKTDQEMKCF
     ICGIERNVFD VVKPGAYDTH ISEEHNMWQY LFFLHYLSEK DPASYNGQEA YVHQQILRRD
     VTFYPIGKSL VLGAMEGGDT SSNKTDGGGS DGGSGRGDGD GDGRSAADEA TAHAVFKLVE
     AALKTSIDPL KRKLEETAES VQGMKELLPQ TGRNLEGTSA SMHPGDLGDT LRPAPPQSSQ
     TRAARK
//
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