ID A0A0N0PA12_PAPXU Unreviewed; 696 AA.
AC A0A0N0PA12;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
GN ORFNames=RR46_01474 {ECO:0000313|EMBL:KPJ02078.1};
OS Papilio xuthus (Asian swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=66420 {ECO:0000313|EMBL:KPJ02078.1, ECO:0000313|Proteomes:UP000053268};
RN [1] {ECO:0000313|EMBL:KPJ02078.1, ECO:0000313|Proteomes:UP000053268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Px {ECO:0000313|EMBL:KPJ02078.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ02078.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR EMBL; KQ459256; KPJ02078.1; -; Genomic_DNA.
DR RefSeq; XP_013171787.1; XM_013316333.1.
DR AlphaFoldDB; A0A0N0PA12; -.
DR STRING; 66420.A0A0N0PA12; -.
DR GeneID; 106120864; -.
DR OrthoDB; 2898719at2759; -.
DR Proteomes; UP000053268; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.90.1520.10; H-NOX domain; 1.
DR Gene3D; 3.30.450.260; Haem NO binding associated domain; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR038158; H-NOX_domain_sf.
DR InterPro; IPR011644; Heme_NO-bd.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR042463; HNOB_dom_associated_sf.
DR InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45655; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR PANTHER; PTHR45655:SF6; HEAD-SPECIFIC GUANYLATE CYCLASE; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07700; HNOB; 1.
DR Pfam; PF07701; HNOBA; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF111126; Ligand-binding domain in the NO signalling and Golgi transport; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Reference proteome {ECO:0000313|Proteomes:UP000053268}.
FT DOMAIN 479..606
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 420..447
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 696 AA; 77984 MW; 214D7122E533FB3B CRC64;
MTCPFRRASS QQQFANGASS KKPELRSRQS SIHLPGPDED DGERNTLTLK NLSEALQLLT
APSNECLHAA VTALTKNQAE HYDKYNCLRR LPDDVKTWRN YAYLEEIYDA VRATDSLNTE
DFMAKLGEYL ILTAFSHNCR LERAFKCLGT NLTEFLTTLD SVHDVLHDQD DVLKDETVEY
EAAFVCTTSR GKIELYLTTE CEPVAYLLVG SLKAIARRLY DTQADIRLMS YTNDPRRFKY
EIKAIPLQQK PTGENSEVTG DSACVASSSK VTDLRIGVAS FCKAFPWHFV TDKRLELVQL
GGGFMRLFGT YLATHGSALG TYFRLLRPRG VSLDFREILK RVNTPFMFCL KIPGSTSLAE
GLEIKGQMVF CSESDSLLFV GSPFLDGLEG LTGRGLFISD IPLHDATRDV ILVGEQARAQ
DGLRRRMDKL KNSIEEASKA VDKEREKNVS LLHLIFPPHI AKRLWLGEKI EAKSHDDVTM
LFSDIVGFTS ICATATPMMV IAMLEDLYSV FDVFCEELDV YKVETIGDAY CVASGLHRKI
ETHAPQIAWM ALRMVETCAQ HLTHEGHPIK MRIGLHTGTV LAGVVGKTML KYCLFGHNVT
LANKFESGSE PLKINVSPTT YKWLINFPGF EMEPRDRSCL PNSFPKDIPG TCYFLHRYKH
PGTDPSASQV QHIQDALIDF GIGQGKSVHV DTEEPT
//
